Canon Kabushiki Kaisha

Hidehito Tochio

Tetsuya Yano

Hidetoshi Tsuzuki

Tetsuya Matsuda

Teruyuki Kondo

Yoshinori Tomida

Kimihiro Yoshimura

Katsuaki Kuge

Hiroki Miura

Hiroshi Tsujita

Zainul Abedin Siddique

Shingo Matsuki

Michiko Narazaki

Masato Minami

Fumio Yamauchi

Shinsuke Sando

Yasuhiro Aoyama

Masahiro Shirakawa

Yoshinori Hasegawa

Yu Kimura

Hisatsugu Yamada

Fuminori Sugihara

As a substance used as a contrast agent for a method of nuclear magnetic resonance analysis or a method of magnetic resonance imaging, a substance with high selectivity and high sensitivity was demanded. According to the present invention, when a polymer having, in a side chain thereof, a sequence of aH&#x2014;C&#x2014;N,H&#x2014;N&#x2014;C orH&#x2014;C&#x2014;C bond, that is, a structure labeled with stable isotopes ofC andN, is used, the abundance of such a sequence in one molecule can be increased, and hence, high selectivity and higher sensitivity can be attained when used as a contrast agent.

Polymer, contrast agent for nuclear magnetic resonance analysis or magnetic resonance imaging using the polymer, compound and method of nuclear magnetic resonance analysis and method of magnetic resonance imaging using the polymer

A core of a cyclic structure represented by (&#x2014;N&#x2014;(CH)&#x2014;)is bonded to a dendrimer-type side chain with a specific branched structure at all nitrogen atoms in the core to produce a compound with a specific structure for producing a metal complex that exhibits a T1-reducing effect, and the resulting compound is coordinated to a metal ion that has a T1-reducing effect to obtain a metal complex that exhibits an excellent T1-reducing effect which is useful as an effective component of an MRI contrast agent and an MRI contrast agent using the same.

Aza metal complexes

AZA compounds and production method thereof, and metal complexes as MRI contrast agents

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Kyoto, Japan

Hidehito Tochio