Toyama Chemical Co., Ltd.

Hidehiko Tanaka

Yoichi Taniguchi

Junichi Yokotani

Eiji Hara

Hitoshi Akitsu

Shuzo Anzai

The anthranilic acid derivative or the salt thereof represented by the general formula wherein Rand Rare hydrogen atom, or the like; Ris a phenyl, cycloalkyl or bicyclic heterocyclic group which may be substituted, or the like; Ris a phenyl, cycloalkyl or pyridyl group which may be substituted, or the like; Xis an alkylene or alkenylene group which may be substituted or a bond; Xis the general formula &#x2014;X&#x2014;X&#x2014; or &#x2014;X&#x2014;X&#x2014;, wherein Xis a sulfur atom, an imino group or a bond, or the like; Xmeans an alkylene or alkenylene group which may be substituted or a bond; is useful for a remedy such as rheumatoid arthritis, osteoarthritis and carcinoma, because it shows MMP&#x2014;13 production inhibitory effect.

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Toyama, Japan

Hidehiko Tanaka