Sankyo Company, Limited

Hidehiko Furukawa

Tokio Tani

Ichiro Kawashima

Yo Takiguchi

Toshinori Ohmine

Makoto Koizumi

Masakatsu Kaneko

Jun Ohsumi

Hitoshi Hotoda

Kenji Momota

Yo Takiguichi

Ohmine, Toshinori

Kawashima, Ichiro

A composition and method of treatment or prophylaxis of a viral infection in a mammal, such as a human, are provided. The compounds in the composition and which are administered in the method, are oligodeoxyribonucleic acid derivatives of the formula (1): ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen atoms, alkyl groups, aryl groups, and anthraquinonyl groups; Z is carbon or silicon; or R.sub.2, R.sub.3 and Z together represent fluorenyl or xanthenyl; R.sub.4 is a hydrogen atom, an alkyl group or an aryl group; Y.sub.1, Y.sub.3 and Y.sub.4 are oxygen, sulfur or &gt;NH; Y.sub.2 is oxygen, sulfur, &gt;NH, alkylene or phenylene; X is an alkylene group; m and n are each 0 to 10; and B is an oligodeoxyribonucleotide of a chain length of 3 to 9, or salts thereof.

Composition and method for the treatment or prophylaxis of viral

Compounds for the treatment or prophylaxis of a viral infection in a mammal, which may be human, are provided. The compounds are oligodeoxyribonucleic acid derivatives, and a novel route to such compounds is also provided together with intermediates of more general utility. The active compounds are of the general formula (1): ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen atoms, alkyl groups, aryl groups as defined, and anthraquinonyl groups as defined; Z is carbon or silicon; or R.sub.2, R.sub.3 and Z together represent fluorenyl or xanthenyl; R.sub.4 is a hydrogen atom, an alkyl group as defined, an aryl group as defined; Y.sub.1, Y.sub.3 and Y.sub.4 are oxygen, sulfur or &gt;NH; Y.sub.2 is oxygen, sulfur, &gt;NH, alkylene or phenylene; X is alkylene group as defined; m and n are 0 to 10; and B is an oligodeoxyribonucleotide of chain length 3 to 9; or salts thereof.

Modified oligodeoxyribonucleoditides

Human pancreatic elastase can now be obtained from a genetically engineered source.

Human pancreatic elastase

Human pancreatic elastase I can be obtained by genetic engineering.

Human pancreatic elastase I

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Tokyo, Japan

Hidehiko Furukawa