Kyowa Hakko Kogyo Co., Ltd.

Kyowa Hakko Kirin Co., Limited

Other

Shin Nihon Chemical Co., Ltd.

Hideharu Anazawa

Nobuo Hanai

Kazuyasu Nakamura

Motoo Yamasaki

Kazuhisa Uchida

Yutaka Kanda

Emi Hosaka

Toyohide Shinkawa

Naoko Yamane

Susumu Imabeppu

Tadashi Nagashima

Akiko Furuya

Yoko Kato

Masamichi Koike

Seiji Sugimoto

Akihiro Iida

Kiyoshi Takatsu

Keiichi Yano

Hidemasa Kondo

Tadanori Yamamura

Satoshi Kuroyanagi

Tatsuya Tange

Syunichi Kaneko

Kenji Shibata

Hiromichi Suzuki

Hiroyuki Ishida

Tadashi Yoshida

Satoshi Nakagawa

Shiro Akinaga

Tatsuya Tamaoki

Yukimasa Shiotsu

Yukiyoshi Ito

Sadao Teshiba

Hiroaki Motoyama

Haruhiko Yokoi

Kinya Yamashita

Tatsuo Suda

Shuichi Ishino

Kazumi Araki

Emi Shoji

Taisuke Nakata

Shigeru Kamimori

Noboru Konishi

Takao Saruta

Yuzuru Ishimura

Shu Wakino

Osamu Mikuni

Toshiaki Monkawa

Matsuhiko Hayashi

Toshimasa Shinki

Hiroko Shimada

Hideki Oda

Toshitsugu Ozeki

Kazuhisa c/o Head Office Kyowa Kogyo Co Ltd Uchida

Emi c/o Biofrontier Laboratories Kyowa Hakko Kogyo Co Ltd Hosaka

Toyohide c/o Bio Process Research And Development Lab Shinkawa

The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.

Method of modulating the activity of functional immune molecules

Method of modulating the activity of functional immune molecules to platelet-derived growth factor receptor

Method of modulating the activity of functional immune molecules to interleukin-5 receptor protein

The invention relates to methods for modulating the antibody-dependent cellular cytotoxicity of an IgG antibody composition.

Methods for producing antibody compositions with increased ADCC

Method of modulating the activity of functional immune molecules to Her-2

Method of modulating the activity of functional immune molecules to CXCR4 protein

Method of modulating the activity of functional immune molecules to GM2

Method of modulating the activity of functional immune molecules to CD52

The present invention provides monoclonal antibodies and humanized antibodies which react specifically with a human interleukin-5 receptor &#x3b1; chain. The invention also provides hybridomas and transformants which produce the antibodies, the monoclonal antibodies and humanized antibodies, a method for detecting an interleukin-5 receptor &#x3b1; chain immunologically by means of these antibodies, as well as a method for diagnosing and treating diseases such as chronic bronchial asthma by means of the monoclonal antibodies and humanized antibodies. The present invention is useful for diagnosis or treatment of diseases such as chronic bronchial asthma.

Method of treating atopic dermatitis using antibody against human interleukin-5 receptor alpha chain

The invention relates to a method for controlling the activity of an immunologically functional molecules, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having promoted activity.

Method of treatment by administering an antibody to human interleukin-5 receptor &#x3b1; chain

The present invention relates to a fusion polypeptide which comprises a polypeptide having G-CSF activity and a polypeptide having TPO activity and DNA which codes for the fusion polypeptide, to a fusion polypeptide in which a polypeptide having G-CSF activity and a polypeptide having TPO activity are fused via a spacer peptide and DNA which codes for the fusion polypeptide and to a polypeptide in which the fusion polypeptide comprising a polypeptide having G-CSF activity and a polypeptide having TPO activity is chemically modified with a polyalkylene glycol derivative. It also relates to an anemia-treating composition containing the fusion polypeptide as an active ingredient.

hG-CSF fusion polypeptide having c-mpl activity, DNA coding for same and methods of treating anemia using same

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Tokyo, Japan

Hideharu Anazawa