Yamanouchi Pharmaceutical Company Ltd.

Hidefumi Matsui

Masuo Murakami

Kozo Takahashi

Kenichi Tomioka

Ichiro Isaka

Akio Koda

Teruya Kashiwagi

Hiroitsu Kawada

Hiroo Maeno

Kohzi Nakano

Hiroshi Horiguchi

A pharmaceutical composition for rectal administration containing 11.alpha.,15(S)-dihydroxy-20-methoxy-16(S)-methyl-9-oxo-5(cis,13(trans)-pr ostadienoic acid or a water-soluble salt thereof dissolved or dispersed in a lipophilic or hydrophilic base in the presence or absence of a buffer solution or an aqueous organic amine solution.

Pharmaceutical compositions of a prostaglandin compound for rectal use

The oxofuryl ester derivatives of 6-(.alpha.-amino-phenylacetamido)penicillanic acid, 7-(.alpha.-aminophenylacetamido)-cephalosporanic acid, or 7-(.alpha. -aminophenylacetamide)desacetoxycephalosporanic acid represented by the general formula ##SPC1## Wherein A represents ##SPC2## Wherein R.sup.1 and R.sup.2, which may be the same or different, each represents a hydrogen atom or a lower alkyl group, said R.sup.1 and R.sup.2 may form together a 1,3-butadienylene group, R.sup.3 represents a hydrogen atom or an acetoxy group, and Means a single bond or a double bond, and acid addition salts of them. When those compounds are orally administered, they are readily absorbed by the intestines and show antibacterial activity by splitting their ester bonds. The rate of absorption of the compounds by the intestines are higher and the toxic property of them is less than those of known compounds similar to the above compounds.

Novel oxofuryl ester derivatives of penicillin and cephalosporin

Growing community of inventors

Ageo, Japan

Hidefumi Matsui