Kyowa Hakko Kogyo Co., Ltd.

Hidee Ishii

Kenji Ohmori

Hiroyuki Obase

Etsuo Oshima

Akira Karasawa

Kazuhiro Kubo

Akio Ishii

Ichiro Miki

Haruhiko Manabe

Fumio Suzuki

Yoshisuke Nakasato

Etsuo Ohshima

Michio Ichimura

Soichiro Sato

Kyoichiro Iida

Koji Yanagawa

Takashi Kawakita

Tohru Matsuzaki

Rie Koike

Katsuichi Shuto

Toshiaki Kumazawa

Tadafumi Tamura

Shizuo Otaki

Derivatives of benzofuran or benzodioxazole compounds

Derivatives of benzofuran or benzodioxole

Novel tricyclic compounds having a TXA.sub.2 antagonizing activity represented by formula (I): ##STR1## possess a potent antagonizing against thromboxane A.sub.2 and also an antiallergic and/or antihistaminic activity, and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.

Tricyclic thromboxane A.sub.2 antagonists

Novel tricyclic compounds having a TXA.sub.2 antagonizing activity represented by formula (I): ##STR1## possess a potent antagonizing action against thromboxane A.sub.2 and also an antiallergic and/or antihistaminic acitvity, and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.

Novel dibenz[b,e]oxepin derivatives are employed in the treatment and control of allergic conditions such as allergic asthma and also employed in the treatment of inflammation.

Dibenz[b,e]oxepin derivative and pharmaceutical compositions thereof

Novel tricyclic compounds having a TXA.sub.2 antagonizing activity represented by formula (I): ##STR1## possess a potent antagonizing action against thromboxane A.sub.2 and also an antiallergic and/or antihistaminic activity, and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.

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Shizuoka, Japan

Hidee Ishii