Kuraray Co., Ltd.

Agency of Industrial Science and Technology

Ministry of International Trade & Industry

Agency of Industrial Science and Technology Ministry of International

Hideaki Yamada

Yoshiaki Omura

Masao Tanihara

Toshihide Nakashima

Koichi Takakura

Kiichiro Oka

Akira Kobayashi

Michihiro Nakamura

Hitoshi Tsuruta

Satoshi Imazato

Yasuhiko Tsuchitani

Mitsuo Torii

Yukiko Motoyashiki

Nobuyuki Utagawa

A medical adhesive which comprises a polyion complex film formed from a polycationic substance and a polyanionic substance. This medical adhesive provides a sufficient gel strength for adhesion of tissues, and it is superior in handling properties and safety for the living body.

Medical adhesive

An antimicrobial adhesive composition for dental use comprising the following polymerizable monomers: an antimicrobial monomer, an monomer containing at least one acidic group, and a monomer containing at least one alcoholic hydroxy group, in combination with water and a polymerization catalyst.

Antimicrobial adhesive composition for dental uses

A human IgG.sub.1 type monoclonal antibody which possesses a molecular weight in the range of 180,000.+-.20,000 as measured by the method of polyacrylamide gel electrophoresis performed in the presence of sodium dodecyl sulfate and is specific to nicotinic acetylcholine receptor. The human IgG.sub.1 type monoclonal antibody mentioned above is produced by a method which comprises fusing human cells capable of producing an antibody against nicotinic acetylcholine receptor with propagable human cells thereby giving rise to a hybridoma capable of producing the aforementioned human IgG.sub.1 type monoclonal antibody, selecting the hybridoma from the production of the fusion, culturing the hybridoma thereby giving rise to the aforementioned human IgG.sub.1 type monoclonal antibody, and selecting the antibody from the cultured medium. The hybridoma mentioned above is also identified.

Human IgG.sub.1 monoclonal antibody specific for the nicotinic

There is disclosed an adsorbent, comprising a carrier on which is immobilized a peptide possessing an ability to bind to the human antibody to the nicotinic acetylcholine receptor and represented by the formula:

Adsorbent, method for production thereof, and method for use thereof

A method for measuring trace amounts of analyte substance(s), which utilize a pH electrode is disclosed. This method is by far simpler than conventional optical detecting systems. The apparatus for practicing the method is also disclosed. By the use of pH electrode, the apparatus is compact, inexpensive and easy to operate, and hence usable in small-size and medium-size hospitals or clinical laboratories and by patient's bedside.

Method and apparatus for the measurement of analyte substances

A monoclonal anti-idiotypic antibody specific to a human IgG.sub.1 type monoclonal antibody possessing specificity to nicotinic acetylcholine receptor; a method for the production of the aforementioned monoclonal anti-idiotypic antibody by the steps of immunizing an animal with a human IgG.sub.1 type monoclonal antibody specific to nicotinic acetylcholine receptor, collecting antibody-producing cells from the animal, fusing the collected cells with neoplastic cells, selecting from the product of fusion a hybridoma capable of producing a monoclonal anti-idiotypic antibody specific to the human IgG.sub.1 type monoclonal antibody possessing specificity to nicotinic acetylcholine receptor, propagating the selected hybridoma thereby giving rise to said monoclonal anti-idiotypic antibody, and collecting the produced monoclonal anti-idiotypic antibody; and use of the monoclonal anti-idiotypic antibody as a reagent and as an adsorbent.

Monoclonal anti-idiotypic antibody, method for production thereof, and

A peptide is disclosed which is represented by the formula:

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Kurashiki, Japan

Hideaki Yamada