Otsuka Pharmaceutical Company, Limited

Hideaki Satou

Satoshi Yamada

Takashi Suzuki

Takashi Nakagawa

Nobuaki Ito

Kuninori Tai

Makoto Sakamoto

Koichi Yasumura

Michinori Tanaka

Seiji Akamatsu

Keizo Kan

Takumi Sumida

Yutaka Kojima

Yasuo Yanagihara

Noriaki Takemura

Keisuke Miyajima

Tae Fukushima

Kazuhisa Sugiyama

Hideki Takasu

Naoto Ohi

Takeshi Kodama

Kunihiko Kiyono

Takuya Shitsuta

Mitsuhiro Okuno

Kenji Watanabe

Hitoshi Nagao

Hironori Tsutsui

Shuji Matsumura

The present invention provides a novel compound, which has an excellent effect of suppressing the generation of collagen and less side effects, with being excellent in terms of safety. The compound of the present invention is represented by the following general formula (1): [wherein Xrepresents a nitrogen atom or a group &#x2014;CH&#x2550;; Rrepresents a group &#x2014;Z&#x2014;R, wherein Z represents a group &#x2014;CO&#x2014;, a group &#x2014;CH(OH)&#x2014;, or the like, and Rrepresents a 5- to 15-membered monocyclic, dicyclic, or tricyclic, saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms, or sulfur atoms; Rrepresents a hydrogen atom, a halogen atom or a lower alkylene group; Y represents a group &#x2014;O&#x2014;, a group &#x2014;CO&#x2014;, a group &#x2014;CH(OH)&#x2014;, a lower alkylene group, or the like; and A represents a group or the like, wherein Rrepresents a hydrogen atom, a lower alkoxy group, or the like, p represents 1 or 2, and Rrepresents an imidazolyl lower alkyl group or the like.

Aromatic compounds for suppressing the generation of collagen

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Tokushima, Japan

Hideaki Satou