Lintec Corporation

The Green Cross Corporation

Hideaki Okabe

Eiji Suzuki

Takanori Saito

Kazuya Katoh

Yuichi Mizukami

Yasushi Sekiyama

Masaru Hoshi

Shuzo Nakagawa

Hiroshi Nagaki

Masao Kogure

Tsuneji Nagai

Ichiro Tsuchida

Rui Saito

Akio Kabuto

Yusaku Sugiura

Kozo Takayama

A process for producing an oral preparation containing a first water-swellable gel-forming layer and a second water-swellable gel-forming layer as outermost layers, a medicine being sealed in an inner space formed by bonding the periphery of the first water-swellable gel-forming layer and the periphery of the second water-swellable gel-forming layer either directly or via an adhesive layer, the process including (a) a step of forming a first water-swellable gel-forming layer, (b) a step of forming a recess in a predetermined area of the first water-swellable gel-forming layer, (c) a step of filling the recess with a medicine to obtain a medicine-containing body, and (d) a step of forming a second water-swellable gel-forming layer over the medicine-containing body directly or via an adhesive layer so that the first water-swellable gel-forming layer and the second water-swellable gel-forming layer are bonded around the recess, and a process for continuously producing the oral preparation are disclosed. According to the above process for producing an oral preparation, an oral preparation in which the medicine is completely masked so that the medicine can be administered without a problem of bitterness and odor of the medicine can be efficiently produced without causing the medicine to deteriorate due to heat history, without a loss of the medicine, and without a limitation to the amount of the medicine to be added.

Process for producing preparation for oral administration

This invention relates to a radiation-resistant acrylic adhesive composition with less reduction in the adhesion thereof upon irradiation with radiations, which composition comprises an acrylic polymer and a radiation-resistant agent, and a radiation-resistant adhesive product comprising the composition.

Method of sterilizing a radiation-resistant medical adhesive product

A blackhead removing agent, a blackhead removing sheet and a method for producing the blackhead removing sheet are disclosed. The blackhead removing sheet comprises a base layer which is composed of a nonwoven fabric having the fineness of 0.0001 denier or more but less than 0.1 denier, and a blackhead removing layer consisting of the blackhead removing agent that contains a water-soluble macromolecular compound as a primary component. The blackhead removing agent comprises a water-soluble macromolecular compound, a filler, and a plasticizer that is compatible with the water-soluble macromolecular compound. The amount of the plasticizer in the blackhead removing agent is less than 0.01 parts by weight with respect to 100 parts by weight of the water-soluble macromolecular compound. The water-soluble macromolecular compound preferably includes a copolymer of N-vinyl-2-pyrrolidone and vinyl acetate as a primary component.

Blackhead removing sheet and method for producing blackhead removing sheet

A blackhead-removing face pack sheet with superior ease of use and blackhead-removing capacity is provided. The blackhead-removing face pack sheet,is formed from a laminate which comprises a gas-permeable and flexible base layer,and a pack material layer,the primary component of which is a copolymer of vinyl acetate and N-vinyl-2-pyrrolidone. The base layer,comprises a porous material such as a nonwoven fabric, and part of it is impregnated or embedded with the pack material constituting the pack material layer,This gives a high force of adhesion between the base layer,and the pack material layer

Blackhead-removing face pack sheet

A transdermal therapeutic formulation is made of a composition comprising a polymer and ingredients mixed with the polymer which are a pharmacologically active substance, an alcohol, a percutaneous absorption promoter utilized according to necessity and water utilized according to necessity. The polymer comprises lipophilic monomer units and hydrophilic monomer units in a specific ratio. The alcohol, the percutaneous absorption promoter and water are mixed with the polymer in specific amounts. The transdermal therapeutic formulation has excellent percutaneous absorption, has many kinds of applicable pharmacologically active substances, shows good stability of percutaneous absorption with time because of absence of crystallization of the pharmacologically active substance, has good adhesive strength and thus favorably utilized as transdermal therapeutic plaster.

Transdermal therapeutic formulation and a method of administration

An article of manufacture in the form of a gel pharmaceutical formulation for local anesthesia is prepared by a process comprising: coating a supporting substrate, which preferably is porous, e.g., a non-woven fabric, and has an impervious backing sheet, with a matrix of a copolymer of alkyl (meth)acrylates and (meth)acrylic acid and a local anesthetic whereby the matrix penetrates the substrate, crosslinking the copolymer in the matrix to form a polymer/drug matrix, and coating the surface of the matrix with an aqueous fluid, thereby converting the matrix into a gel and preferably covering the gel matrix with an impervious protective sheet. The product has excellent percutaneous absorption, provides local anesthesia easily just by attaching the formulation to the skin, enables elimination of various kinds of pain, such as the pain at the time of hypodermic injection, can be removed easily from the skin, and causes no soiling of fingers, hands or cloths.

Gel pharmaceutical formulation for local anesthesia

An self-adhesive article which is produced by forming an adhesive layer from an adhesive consisting essentially of a polymer of which is soluble in or swellable by an iso-thiocyanate, impregnating the adhesive layer with an iso-thiocyanate to provide a biocidal self-adhesive, and applying the biocidal self-adhesive to at least one surface of a base material. A high concentration of the iso-thiocyanate can be held in the adhesive layer, and the self-adhesive article is put to uses intended for the purpose of providing bactericidal, fungicidal and microbiocidal effects in building and food-related fields and the like.

Biocidal self adhesive and process for producing the same, as well as

Biocidal self-adhesive and process for producing the same, as well as

A percutaneous absorption promoter comprises a derivative of amino acid in which the amino group has or does not have an acyl substituent or a hydrocarbon substituent, the carboxylic group has a hydrocarbon substituent and the part between the amino group and the carboxylic group has a specified structure. A tape plaster comprises the percutaneous absorption promoter described above. The method utilizes the the percutaneous absorption promoter described above. The percutaneous promoter of the invention has excellent ability of promoting the percutaneous absorption of pharmacologically active substances and excellent safety simultaneously, capable of delivering the desired pharmacologically active substances rapidly to the location of treatment or to all parts of the body through the circulating system and effective for curing various kinds of disease. The tape plaster comprising it and the method of promoting percutaneous absorption by utilizing it have the same advantages.

Percutaneous absorption promoter, a tape plaster and a method of

A transdermal therapeutic formulation comprising d-limonene and at least one pharmaceutically active substance wherein the content of the d-limonene is in the range from 0.1 to 2 weight percent, based on the total amount of the formulation. The transdermal therapeutic formulation has an excellent percutaneous absorption, is safe and is capable of delivering desired pharmaceutically active substances to a desired location of treatment or to the entire body of a patient through the circulatory system and is thus effective for curing various diseases.

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Urawa, Japan

Hideaki Okabe