Kemphys Ltd.

Research Foundation Itsuu Laboratory

Research Founation Itsuu Laboratory

Hideaki Muratake

Koichi Shudo

Ai Ito

Masayuki Noguchi

A compound represented by the formula (I) [at least one of R, R, and Rrepresents a cyclic alkyl group, the remaining represents a linear or branched alkyl group; n represents 0 or 1; Rrepresents an amino group or &#x2014;(CX)&#x2014;COOH (m represents 0 to 3, and X represents hydrogen atom); and Rrepresents &#x2014;(CY)&#x2014;COOR(p represents 0 to 3, Y represents hydrogen atom, and Rrepresents hydrogen atom or an alkyl group)], or a salt thereof. 

Silicon-containing carboxylic acid derivative

A compound represented by the formula (I) [Rto Rrepresent an alkyl group, an alkenyl group, and the like; n represents 0 or 1; Rrepresents an amino group or &#x2014;(CX)&#x2014;COOH (m represents 0 to 3, and X represents hydrogen atom); Rrepresents &#x2014;(CY)&#x2014;COOR(p represents an 0 to 3, Y represents hydrogen atom, and Rrepresents hydrogen atom or an alkyl group)], or a salt thereof. 

A compound represented by the following general formula (I): [wherein Rand Rrepresent an alkyl group, X represents &#x2014;S&#x2014;, &#x2014;O&#x2014; or &#x2014;NH&#x2014;, Y represents C or N, Rrepresents hydrogen atom or a Calkyl group, Z represents &#x2014;CO&#x2014;N(R)&#x2014; (Rrepresents hydrogen atom or a Calkyl group) or &#x2014;C(R)&#x2550;C(R)&#x2014;CO&#x2014;NH&#x2014; (Rand Rrepresent hydrogen atom or a Calkyl group), Ar represents an aryldiyl group or a heteroaryldiyl group, and Rrepresents &#x2014;COOH, &#x2014;OCH&#x2014;COOH, &#x2014;CH&#x2014;COOH, or &#x2014;CH&#x2014;CH&#x2014;COOH], which has a retinoid action and is useful as an active ingredient of a medicament.

5-membered heterocyclic compound

A compound represented by the following general formula (I): [Rto Rrepresent hydrogen atom, an alkyl group, or a trialkylsilyl group, X represents &#x2014;NH&#x2014;CO&#x2014;, &#x2014;CO&#x2014;NH&#x2014;, &#x2014;N(COR)&#x2014;CO&#x2014;, &#x2014;CO&#x2014;N(COR)&#x2014; (Rand Rrepresent a lower alkoxy group, or a carboxy-substituted phenyl group) etc.; and Z represents &#x2014;Y&#x2014;CH(R)&#x2014;COOH, &#x2014;CHO, &#x2014;CH&#x2550;CH&#x2014;COOH, or &#x2014;COOR(Y represents a single bond, &#x2014;CH&#x2014;, &#x2014;CH(OH)&#x2014;, &#x2014;CO&#x2014;, &#x2014;CO&#x2014;NH&#x2014;, or &#x2014;CO&#x2014;NH&#x2014;CH&#x2014;CO&#x2014;NH&#x2014;, Rrepresents hydrogen atom or a lower alkyl group, and Rrepresents hydrogen atom, &#x2014;CH(R)&#x2014;COOH(Rrepresents hydrogen atom, a lower alkyl group, or hydroxy group), &#x2014;[CHCH&#x2014;O]&#x2014;CH&#x2014;CH&#x2014;OH, &#x2014;CH&#x2014;O&#x2014;[CHCH&#x2014;O]&#x2014;CH&#x2014;OH, or &#x2014;[CH(CH)&#x2014;CO&#x2014;O]&#x2014;CH(CH)&#x2014;COOH (m, n and p represent an integer of 1 to 100))], a salt thereof or an ester thereof, which has a property of being converted into a retinoid after absorption in vivo.

Growing community of inventors

Tokyo, Japan

Hideaki Muratake