Sysmex Corporation

Toa Medical Electronics Co., Ltd.

Hideaki Matsumoto

Kinya Uchihashi

Aya Konishi

Yuji Itose

Takaaki Nagai

Yuichi Hamada

Hideki Hirayama

Ayumu Yoshida

Takashi Sakata

Yoichi Nakamura

Tokuhiro Okada

Keiichi Inami

Junichi Shiraishi

Keiko Moriyama

Masayoshi Hayashi

Shunichi Kumagai

Shion Imoto

Meiyi Jiang

Katsuyasu Saigo

This blood analyzer includes a sample preparation portion preparing a measurement sample free from a labeling substance from a blood sample and a hemolytic agent free from a labeling substance, a light information generation portion generating fluorescent information and at least two types of scattered light information from the measurement sample and a control portion performing a first classification of white blood cells in the measurement sample into at least four groups of monocytes, neutrophils, eosinophils and others on the basis of the fluorescent information and the two types of scattered light information.

Blood analyzer, blood analysis method and hemolytic agent

This blood analyzer includes a sample preparation portion preparing a first measurement sample containing a blood sample and a hemolytic agent and a second measurement sample containing the blood sample, the same hemolytic agent as the hemolytic agent and a staining agent and a control portion classifying white blood cells in the first measurement sample into at least four groups of monocytes, neutrophils, eosinophils and others on the basis of fluorescent information and two types of scattered light information generated by a light information generation portion and classifying blood cells in the second measurement sample into at least malaria-infected red blood cells and others on the basis of fluorescent information and scattered light information generated by the light information generation portion.

Blood analyzer, blood analysis method, hemolytic agent and staining agent

An animal blood cell measuring apparatus comprising: a specimen preparation section for preparing a measurement specimen from blood of an animal; a characteristic information obtaining section for obtaining characteristic information indicating a characteristic of the measurement specimen, from the measurement specimen prepared by the specimen preparation section; and a controller configured for performing operations comprising: (a) classifying aggregate reticulocytes contained in the blood from other blood cells, based on the characteristic information obtained by the characteristic information obtaining section; and (b) outputting information regarding a number of the classified aggregate reticulocytes.

Animal blood cell measuring apparatus

A method for analyzing blood cells in a whole blood sample obtained from a cat is provided. An electrical measurement result and an optical measurement result of the whole blood sample are acquired. The electrical measurement result is obtainable by electrically measuring blood cells in the whole blood sample and the optical measurement result is obtainable by optically measuring blood cells in the whole blood sample. On the basis of the electrical measurement result and the optical measurement result, volume of red blood cells in the whole blood sample is calculated.

Sample measuring apparatus and sample measuring method

A sample measuring apparatus of measuring a component in a biological sample, comprising: an input section for inputting a sample species of a biological sample; a measurement sample preparation section for preparing a measurement sample by mixing the biological sample with a reagent; a first measurement section; a second measurement section being different from the first measurement section; a measurement sample supply section for supplying the measurement sample prepared in the measurement sample preparation section to at least one of the first measurement section and second measurement section; and a control section for controlling the measurement sample supply section based on the inputted sample species.

A method for classifying leukocytes in animal blood is described. In the method, a measurement sample is prepared by mixing a canine or feline blood sample with a lysing reagent. Erythrocytes are lysed and leukocytes are shrunk in the measurement sample. The data correlated with the size of leukocytes in the measurement sample are measured. The leukocytes, on the basis of the measured data, are classified into a first group containing lymphocytes, a second group containing neutrophils and monocytes and a third group containing eosinophils.

Method and reagent for classifying leukocytes in animal blood

A method for quantitatively analyzing fragmented red blood cells includes the steps of: preparing a two-dimensional particle distribution diagram on the basis of a scattered light intensity and fluorescent light intensity; establishing a red blood cell distribution area on the distribution diagram, and counting particles falling within the red blood cell distribution area for determination of the total number A of red blood cells; establishing a fragmented red blood cell distribution area in a region in which the scattered light intensity and the fluorescent light intensity are low within the red blood cell distribution area, and counting particles falling within the fragmented red blood cell distribution area for determination of the number B of fragmented red blood cells; and calculating a value B/A, and calculating a content by percentage F of the fragmented red blood cells from a conversion function F&equals;f(B/A).

Method for quantitatively analyzing fragmented red blood cells

A reagent for staining malaria infected cells and a method for detecting malaria infected cells using the same, wherein the regent is a staining solution comprising at least one first dye of an Auramine analogue having the formula (I): ##STR1## wherein R.sub.1 to R.sub.6 represents a hydrogen atom, or a methyl or ethyl group, X.sub.1 represents a halogen atom, and at least one second dye of a condensed benzene derivative having the formula (II): ##STR2## wherein A represents ##STR3## R represents a C.sub.1-6 alkyl group, X.sub.2 represents a halogen atom, Y represents --CH.dbd. or --NH--, n represents 0 or 1, and B represents ##STR4## or a phenyl group substituted with 2 lower alkoxy group or with 1 di-lower alkylamino group. A test sample is treated with reagent to stain malaria infected cells. The stained malaria infected cells are then optically detected.

Reagent for detecting malaria infected cells and a detecting method for

A method which comprises using a specified dye taken up by erythrocytic nucleated cells so that their nuclei are stained and can be readily differentiated from other cells by measurement with a flow cytometer is disclosed. The method relies basically upon flow cytometry by two-step staining that uses a first fluid that is an acidic hypotensive fluorescent dye solution and a second fluid that is a solution that changes the osmorality and pH of the first fluid. The first fluid further contains a fluorescent dye that diffuses into erythroblasts to specifically stain their nuclei, and a group of erythroblasts is separated from other cell groups on the two-dimensional plot constructed with the flow cytometer, whereby the results of erythroblast differentiation are computed.

Method of differentiating erythroblasts from other cells by flow

A particle size distribution analyzer comprising a particle detector adapted to produce signals in response to the sizes of particles by electrical or optical differences between a liquid and the particles dispersed therein, a plurality of comparators connected in parallel to said particle detector for producing pulses in correspondence with said signals, counters connected to each of said comparators for counting said pulses, a data input/output unit connected to each individual counter, whereby said input/output circuit receives signals sent in parallel from said counters, a keyboard unit connected to said input/output circuit operative to enable various conditions to be input from the outside, a central processing unit circuit, a read only memory and, a random access memory connected to said later input/output unit for statistically processing the pulse received, and a data output unit connected to said data input/output unit, said data output unit including at least a recorder.

Growing community of inventors

Takasago, Japan

Hideaki Matsumoto