Terumo Kabushiki Kaisha

Hideaki Kito

Yukio Seita

Katsuhiro Takanashi

Mitsuhide Nakagawa

Masaaki Kasai

Kouichi Tachikawa

Shinsuke Yokomachi

Yasushi Nemoto

A syringe (and a prefilled syringe) of a structure with ventilation means allowing a pusher to be easily pushed or pulled in use, providing an excellent operability of discharging (injecting) chemicals, making it hard for foreign matter such as dirt and dust to enter into a syringe outer tube when not in use during storage or transporation, capable of assuring, by itself, the sanitation of the syringe outer tube when not in use, and allowed to be shipped without individually packaging the syringe with packaging material, wherein, as more desirable embodiments, the aseptic condition in the outer tube can be surely maintained even if the push and pull operations of the pusher are performed and, even if the pusher is pushed when not in use, a gasket does not move in tip direction and the arrangement of the pusher at the time of shipping can be stably maintained.

Syringe and prefilled syringe

A permeable membrane excellent in biocompatibility, produced by forming coagulation by melting method in the form of a membrane a terminal-modified polyamide, i.e. a polyether amide comprising component units represented by the following structural formula (I), (II), (III), or (IV), possessing hydrocarbon groups of one to 22 carbon atoms at the terminals thereof, and having a molecular weight in the range of from 10,000 to 100,000, said terminal-modified polyamide being such that the number of said hydrocarbon groups is in the range of from 5 to 100% based on the number of all of the terminal groups of said polyether amide, placing said membrane in contact with a medium capable of swelling or partially dissolving said membrane, and further placing the resultant altered membrane in contact with a solution consisting mainly of a nonsolvent for said polyether amide. ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 are independently a linear or branched alkylene group of two to four carbon atoms, R.sup.4,R.sup.5, and R.sup.6 are independently an aliphatic, alicyclic, or aromatic hydrocarbon group of two to 36 carbon atoms, n is a numeral in the range of from 0 to 180, and m is a numeral in the range of from 1 to 400.

Permeable membrane excellent in biocompatibility

A permeable membrane excellent in biocompatibility, produced by forming coagulation by melting method in the form of a membrane a terminal-modified polyamide, i.e. a polyether amide comprising component units represented by the following structural formula (I), (II), (III), or (IV), possessing hydrocarbon groups of one to 22 carbon atoms at the terminals thereof, and having a molecular weight in the range of from 10,000 to 100,000, said terminal-modified polyamide being such that the number of said hydrocarbon groups is in the range of from 5 to 100% based on the number of all of the terminal groups of said polyester amide, placing said membrane in contact with a medium capable of swelling or partially dissolving said membrane, and further placing the resultant altered membrane in contact with a solution consisting mainly of a nonsolvent for said polyether amide. ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 are independently a linear or branched alkylene group of two to four carbon atoms, R.sup.4, R.sup.5, and R.sup.6 are independently an aliphatic, alicyclic, or aromatic hydrocarbon group of two to 36 carbon atoms, n is a numeral in the range of from 0 to 180, and m is a numeral in the range of from 1 to 400.

There is disclosed a hydrophilic porous membrane in which a mixture composed of a surfactant, a hydrophilic polymer which is insoluble to water and alcohol, and a water soluble polymer is retained on the surface of a hydrophobic porous membrane material and/or at inner surface of pores and the surfactant is retained by the hydrophilic polymer. By taking the above constitution, a hydrophilic porous membrane which is restrained in dissolution and generation of foaming and is excellent in safety can be obtained.

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Ashigarakami, Japan

Hideaki Kito