Riken Corporation

Other

The Institute of Physical and Chemical Research

Institute of Biotechnology Applied To Soil Eumycetes

Hideaki Kakeya

Hiroyuki Osada

Susumu Kanazawa

Hiroshi Konno

Yujiro Hayashi

Kimie Kobinata

Hui-ping Zhang

A compound represented by the general formula (I): (I) wherein R represents linear, branched, or cyclic alkyl or aryl; a process for producing the compound; and an antitumor agent containing the compound as an active ingredient.

Compound having antitumor activity and process for producing the same

A compound represented by the general formula (I): (I) wherein R represents linear, branched, or cyclic alkyl or aryl; a process for producing the compound; and an antitumor agent containing the compound as an active ingredient. 

A compound represented by the following formula (I) or a salt thereof which has excellent antitumor activity and angiogenesis inhibitory action in a low oxygen condition, and a medicament such as an antitumor agent and an anti-inflammatory agent which comprises the compound or a physiologically acceptable salt thereof as an active ingredient. 

Substance having antitumor/anti-inflammatory activity

A compound represented by formula (I) wherein Rrepresents hydrogen atom and Rrepresents hydroxyl group, or Rand Rmay combine together to represent oxo group or oxime group; Rrepresents hydrogen atom and Rrepresents hydroxyl group, or Rand Rmay combine together to represent oxo group or oxime group; Rrepresents hydrogen atom and Rrepresents hydroxyl group, or Rand Rmay combine together to represent oxo group or oxime group; Rrepresents hydrogen atom and Rrepresents hydrogen atom, or Rand Rmay combine together to represent oxo group or oxime group; Rand Rrepresent hydrogen atom, an alkyl group, or an alkenyl group. The compound is useful as an active ingredient of a medicament having angiogenesis suppressive activity, apoptosis suppressive activity, and cell cycle inhibitory activity 

PKB-3564 substance with neovascularization inhibitory activity

A compound represented by the following formula (I) or a salt thereof and a medicament such as an angiogenesis inhibitor and an antitumor agent which comprises said compound or a physiologically acceptable salt thereof as an active ingredient.

Angiogenesis inhibitor

An anti-tumor composition containing cytotrienin (I), (II), (III) or (IV) as the active ingredient, which compounds are produced by culturing a bacterium which produces cytotrienin (I), (II), (III) or (IV), in a medium and accumulating cytotrienin (I), (II), (III) or (IV) in the medium and harvesting the product.

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Wako, Japan

Hideaki Kakeya