Zenyaku Kogyo Kabushiki Kaisha

The Kitasato Institute

Hideaki Hanaki

Hiroaki Yamazaki

Seiichiro Kawashima

Keiichi Hiramatsu

Satoshi Omura

Hideki Sato

Hiroshi Tomoda

Yoko Takahashi

Yoshio Tsuchida

Atsuko Matsumoto

Yong-pil Kim

Hidenori Harada

Hirishi Tomoda

Yong-Pil Kim

A microorganism represented by a strain K04-0144 belonging tosp. having ability to produce K04-0144 substance is cultured in the medium, and the isolated K04-0144A substance, K04-0144B substance and K04-0144C substance therefrom have strong antibacterial activities against Gram-positive bacteria including methicillin-resistant(MRSA), consequently these are useful as the therapeutic agents for infectious disease caused by MRSA as well as infectious diseases caused by multidrug including &#x3b2;-lactam antibiotics resistant bacteria. Further, similarly, since the novel K04-0144D substance isolated from the cultured liquid has the action for enhancing the effect of &#x3b2;-lactam antibiotics, which are utilized as the antibacterial agents, in combination with them, it is useful as the therapeutic agent for infectious diseases caused by methicillin-resistant(MRSA) and multidrug including &#x3b2;-lactam antibiotics resistant bacteria.

K04-0144 substance and a process for production thereof

A cephem compound or pharmaceutically acceptable salt thereof represented by the formula I:wherein Rand Rmay be the same or different and each represent hydrogen atom, nitro or cyano; Rrepresents C-Calkyl which may be substituted with carboxyl; Rrepresents hydrogen atom or amino; X represents &#x2014;S&#x2014; or &#x2014;SO&#x2014;, there being no case where both of Rand Rare simultaneously hydrogen atom.

Cephem compounds and ESBL-detecting reagents containing the same

Cephem compounds

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Kanagawa, Japan

Hideaki Hanaki