Nippon Chemiphar Co., Ltd.

Dai Nippon Insatsu Kabushiki Kaisha

Hitachi, Ltd.

Dai Nippon Printing Co., Ltd.

The Kitasato Institute

Asahi Kasei Fibers Corporation

Asahi Kasei Kabushiki Kaisha

Hideaki Fujii

Hiroshi Nagase

Eriko Nakata

Masaaki Hirose

Isao Ooi

Kohei Hayashida

Akiyoshi Saitoh

Takeshi Matsumoto

Yorihiko Sakai

Norikazu Mineo

Norikatsu Ono

Toshihiro Takahashi

Yoshikazu Watanabe

Taiga Goto

Tetsuo Nakazawa

Motohiro Oka

Tatsumi Takahashi

Masashi Nishiyama

Masatoshi Harayama

Hiroshi Ishiga

Hisashi Takahashi

Daisuke Saito

Tatsuya Ogawa

Saori Tanaka

Yoshiyuki Tadokoro

Satoru Tezuka

Kiyoshi Miyaji

A method for therapeutic treatment of pain-associated anxiety or depression in a mammalian subject in need thereof, that includes administering to the subject an effective amount of a pharmaceutical composition containing a morphinan derivative that exhibits an opioid δ receptor agonist activity.

Use of morphinan derivatives for treatment of opioid delta receptor agonist-related disease

A morphinan derivative represented by the following general formula (I): wherein Rrepresents hydrogen, Calkyl, cycloalkylalkyl where the cycloalkyl moiety has 3 to 6 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms, etc.; Rrepresents heterocyclic ring containing 1 to 4 heteroatoms selected from N, O and S and at least one carbon atom as ring-constituting atoms, containing at least one set of adjacent ring-constituting atoms bound by a double bond, and further substituted with at least one oxo group; Y binds to a carbon atom as a ring-constituting atom of R; R, R, and Rrepresent hydrogen, hydroxy, etc.; Rand Rrepresent hydrogen, etc.; Rand Rrepresent hydrogen, etc.; Rand R, which are the same or different, represent hydrogen, etc.; X represents O or CH; and Y represents C(&#x2550;O)); a tautomer or stereoisomer of the compound, or a pharmaceutically acceptable salt thereof, or a solvate thereof is used as an anxiolytic drug, antidepressant, etc.

Morphinan derivative

The present invention relates to a pharmaceutical composition comprising a morphinan derivative that exhibits an opioid &#x3b4; receptor agonist activity. By administering the pharmaceutical composition provided by the present invention, opioid &#x3b4; receptor-related diseases (for example, headache) can be treated or prevented.

Use of morphinan derivative for therapeutic treatment of opioid delta receptor agonist-related disease

A morphinan derivative represented by the following general formula (I): (wherein Rrepresents hydrogen, Calkyl, cycloalkylalkyl where the cycloalkyl moiety has 3 to 6 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms, etc.,

In order to reduce a metal artifact using a short process, without causing image quality deterioration, when a subject containing metal is imaged in an X-ray CT apparatus, the invention is such that a high frequency component is extracted utilizing the fact that a high frequency component is a structure in error projection data, which are a difference between primary corrected projection data wherein at least one portion of an artifact component caused by metal has been removed and photographed projection data acquired by imaging. The high frequency component, extracted while carrying out weighting in order to suppress the metal artifact, is restored to the primary corrected projection data, after which an image is reconstructed. Also, metal projection data used when compiling the primary corrected projection data are calculated from a value that is a CT value corresponding to soft tissue subtracted from a CT value of a metal region.

X-ray CT apparatus, reconfiguration arithmetic apparatus, and X-ray CT image generation method

In a case where helical scanning, etc., is performed in an X-ray CT apparatus, upsampled projection data that more approximates to an observed value is obtained. There is provided an X-ray CT apparatus that improves spatial resolution of an overall effective field of view without reducing rotation speed, in an FFS method of acquiring projection data through moving of an X-ray focus position to a plurality of positions. The X-ray CT apparatus: converts projection data acquired through helical scanning into projection data of normal scanning performed by one rotation; generates a virtual-counter-data space in which virtual counter data are acquired on substantially coincident X-ray transmission path in the converted projection data; performs upsampling in a view direction; and similarly upsamples FFS projection data in the view direction for focus-shifted projection data obtained by performing the helical scanning while causing the X-ray focus position to shift (virtual counter data space generation).

X-ray CT apparatus, upsampling method of projection data, and image reconstruction method

Provided is a filter material which can enhance the particle holding capacity of a filter while keeping the particle capture efficiency thereof and which thus ensures a prolonged filter life. The present invention pertains to a filter material comprising a spun lace nonwoven fabric which contains a thermoplastic synthetic filament nonwoven fabric as the intermediate layer.

Filter material

In an FFS method that improves spatial resolution by moving an X-ray focal spot to multiple positions to acquire projection data, in order to provide an X-ray CT apparatus and an image reconstruction method that enables to improve spatial resolution of the entire effective field of view without reducing a rotational speed, the X-ray focal spot in the X-ray tube deviceis shifted to acquire focal shift projection data (FFS projection data), the virtual view generation unitup-samples the FFS projection data (generates a virtual view) in the view direction, and the reconstruction computing unitreconstructs an image using actual data of the FFS projection data in the central regioncloser to the image center than a predetermined boundary and using the up-sampled projection data in the peripheral regionoutside the boundary in an image reconstruction computing process.

X-ray CT apparatus and image reconstruction method

The present invention relates to a morphinan derivative represented by the following general formula (I), wherein Rrepresents hydrogen, Calkyl, Caryl, etc., Rand R, which are the same or different, represent hydrogen, hydroxy, etc., Rand Rrepresent hydrogen, Calkyl, etc., Rrepresents hydrogen, hydroxy, Calkyl, etc., X represents O or CH, Y represents C&#x2550;O, C(&#x2550;O)O, etc., and m and n, which are the same or different, represent an integer of 0 to 2 (m and n are not 0 at the same time), a tautomer or stereoisomer of the compound, or a pharmaceutically acceptable salt thereof, or a solvate thereof, as well as an analgesic, antianxiety drug, etc. containing the same as an active ingredient. 

A morphinan derivative represented by the following general formula (I): 

A female mold (2, 12, 22, 32, 42, 52, 62) having a desirable pattern is formed on a substrate (1, 11, 21, 31, 41, 51, 61). Next, ceramic material (3, 13, 23, 33, 43, 53, 63) is filled in spaces in the female mold. Thereafter, the female mold is removed by heating the entire substrate, whereby a desirable thick film pattern can be finely and easily formed. The inorganic paste material comprising inorganic liquid vehicle containing water glass as main ingredient and powdery solid dispersed in the inorganic liquid vehicle is used as the ceramic material. The volume change of the inorganic paste material is small during the drying and calcinating processes, thus the inorganic paste material is prevented from being broken.

Method of forming thick film pattern and material for forming thick film

Predetermined barrier ribs 2 are filled with three types of pastes of fluorescent substances 3 for R, G, and B by a screen printing method. Next, a sandblasting process is performed through a sandblasting mask 7. Thereafter, a sintering process is performed. Thus, fluorescent screens are formed on a glass substrate 1 and the wall surfaces of barrier ribs 2. As the sandblasting mask 7, a photoresist 4 is used. By a photolithographic method, a desired pattern of the sandblasting mask 7 can be used. In this manner, fluorescent screens can be formed on the wall surfaces of the barrier ribs as well as the glass substrate 1. The fluorescent screens formed on the wall surfaces of the barrier ribs are in such a parabolic shape that a discharging space defined by the fluorescent screen is widened toward a front plate 11.

Growing community of inventors

Tokyo, Japan

Hideaki Fujii