Japan Science and Technology Agency

Hideaki Ando

Katsuhiko Mikoshiba

Junji Hirota

Akihiro Mizutani

The present invention provides a composition comprising an IPreceptor-binding protein (IRBIT), a nucleic acid that controls the expression and translation of IRBIT, or an antibody against IRBIT for controlling at least one intracellular biological function selected from the group consisting of (1) protein synthesis, (2) phosphatidylinositol metabolism, and (3) intracellular pH.

In vitro control of protein synthesis in mammalian cells by IP3 receptor-binding protein

Analysis of substance capable of binding with inositol-1,4,5-triphosphate (IP) receptor (IPR), preferably with a regulation domain of IPR; analysis of the function of IPR; and establishing of a method of treatment or diagnosis for various malfunctions and diseases associated with IPR. In particular, control of the activity of intracellular Carelease. More specifically, a regulator for the activity of inositol-1,4,5-triphosphate (IP) receptor (IPR), comprised of carbonic anhydrase related protein (CARP); a control agent for intracellular calcium release, comprised of carbonic anhydrase related protein (CARP); and a method of control therewith.

Control of function of intracellular Ca ion

Analysis of substance capable of binding with inositol-1, 4,5-triphosphate (IP) receptor (IPR), preferably with a regulation domain of IPR; analysis of the function of IPR; and establishing of a method of treatment or diagnosis for various malfunctions and diseases associated with IPR. In particular, control of the activity of intracellular Carelease. More specifically, a regulator for the activity of inositol-1,4, 5-triphosphate (IP) receptor (IPR), comprised of carbonic anhydrase related protein (CARP); a control agent for intracellular calsium release, comprised of carbonic anhydrase related protein (CARP); and a method of control therewith.

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Tokyo, Japan

Hideaki Ando