Taisho Pharmaceutical Co., Ltd.

Hideaki Amada

Masakazu Sato

Takaaki Ishii

Noriyuki Miyata

Yuko Kobayashi

Hiroyuki Kakinuma

Hajime Asanuma

Yuko Matsunaga

Hitomi Takahashi

Yuko Tsuchiya

Takahiro Oi

Tetsuya Yabuuchi

Fumiyasu Shiozawa

Tetsuo Takayama

Yohei Kobashi

Hironori Katakai

Takeshi Koami

Yuko Hashimoto

Yuki Iwata

Hiroki Umemiya

Akiko Ikeda

Provided is a novel C-phenyl glycitol compound that may serve as a prophylactic or therapeutic agent for diabetes by inhibiting both SGLT1 activity and SGLT2 activity, thereby exhibiting a glucose absorption suppression action and a urine glucose excretion action. A C-phenyl glycitol compound represented by Formula (I) below or a pharmaceutically acceptable salt thereof or a hydrate thereof  

C-phenyl glycitol compound

A thiazolylimidazole derivative represented by the formula or a pharmaceutically acceptable salt thereof, and an ALK5 inhibitor, an therapeutic agent for alopecia or a hair growth agent having the above as an active ingredient,wherein:  The present invention provides an inhibitory substance against ALK5 which is a TGF-&#x3b2; type I receptor and provides a hair growth stimulant or a hair growth agent based on its novel activities.

Thiazole derivative

There is provided a heteroaryl 5-thio-&#x3b2;-D-glucopyranoside compound of the following formula, which has an inhibitory effect on SGLT2 activity, or a pharmaceutically acceptable salt thereof or a hydrate thereof. There is also provided a pharmaceutical preparation, particularly a prophylactic or therapeutic agent for diabetes, diabetes-related diseases or diabetic complications, which comprises such a compound as an active ingredient. 

Heteroaryl 5-thio-&#x3b2;-D-glucopyranoside derivatives and therapeutic agents for diabetes containing the same

An N-hydroxyformamidine compound of the following formula or a pharmaceutically acceptable salt thereof: wherein R, A and R are as defined herein. The compounds inhibit 20-HETE-producing enzymes, 20-HETE being involved in the effects of causing microvascular constriction or dilation in major organs (e.g., kidneys, cerebral blood vessels) or of inducing cell proliferation.

N-hydroxyformamidine derivatives

A hydroxyformamidine compound represented by the following formula or a pharmaceutically acceptable salt thereof [wherein Rrepresents a substituted morpholino group, a substituted piperidino group, a piperazin-1-yl group, a substituted piperazin-1-yl group, a thiomorpholin-1-yl group, a perhydroazepin-1-yl group, a perhydroazocin-1-yl group, a tetrahydropyridin-1-yl group, a pyrrolin-1-yl group, etc.; X represents a nitrogen atom or a group represented by CR; and Rto Rare the same or different and each represents a hydrogen atom, a Calkyl group, a Calkoxy group, a trifluoromethyl group or a halogen atom.] There is provided a drug which inhibits an enzyme producing 20-HETE participating in a contracting or dilating action for microvessels and an inducing action for cell proliferation in main organs such as kidney and cerebrovascular vessels.

20-hydroxyeicosatetraenoic acid production inhibitors

The present invention relates to an inhibitor for production of 20-hydroxyeicosatetraenoic acid, comprising, as an effective ingredient, specific hydroxyformamidine derivatives or pharmaceutically-acceptable salts thereof. The inhibitors according to the present invention are useful as therapeutic agents for kidney diseases, cerebrovascular diseases, or circulatory diseases. In addition, the present invention also provides novel hydroxyformamidine derivatives or pharmaceutically-acceptable salts thereof.

20-HETE synthase inhibitor

An inhibitor for 20-hydroxyeicosatetraenoic acid production which comprises as the active ingredient a specific hydroxyformamidine derivative or a pharmacologically acceptable salt thereof. It is useful especially as a remedy for kidney diseases, cerebrovascular diseases, or circulatory diseases. The novel hydroxyformamidine derivative or pharmacologically acceptable salt thereof is also provided.

Inhibitor for 20-hete-yielding enzyme

Hydroxyformamidine derivatives and medicines containing the same

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Tokyo, Japan

Hideaki Amada