Shire Human Genetic Therapies, Inc.

Hicham Naimy

Michael F Concino

Muthuraman Meiyappan

Angela Norton

Bettina Strack-Logue

Bohong Zhang

Ann Barbier

Andrea Iskenderian

Dianna Lundberg

Alla Romashko

Patrick Anthony John Haslett

Lieh Yoon Low

Yongchang Qiu

Angela W Norton

A targeted therapeutic including a lysosomal enzyme and a lysosomal targeting moiety that is a peptide containing at least one N-linked glycosylation site. Methods of producing the targeted therapeutic may include nucleotide acids encoding the same and host cells co-expressing GNPT. Pharmaceutical compositions comprising the targeted therapeutic and methods of using the same to treat a lysosomal storage disease.

Mannose-6-phosphate bearing peptides fused to lysosomal enzymes

Detecting glycosaminoglycans (GAGs) and/or determining the level of one or more glycosaminoglycans can be useful, e.g., in identifying or monitoring various medical conditions, the status of patients having various medical conditions, and/or the response to treatment of individuals having various medical conditions. The present invention provides methods for detecting glycosaminoglycans and/or determining the level of glycosaminoglycans through the use of, e.g., mass spectrometry.

Determination of glycosaminoglycan levels by mass spectrometry

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Lexington, MA, United States of America

Hicham Naimy