Nektar Therapeutics

Hi-Shi Chiang

David B Bennett

Bing Yang

Cynthia L Stevenson

David D Lesikar

Kirsten M Cabot

Jayne E Hastedt

David K Gong

John S Patton

Ronald Keith Wolff

Benjamin Lee Hughes

Geraldine Venthoye

Darrel LaVern Allen

Sudha Nagarajan

Russ Lehrman

Joanne Greene

S Russ Lehrman

Cheryl L M Stults

Mary Stiff-Torvik

William David Roeder

Provided are stabilized follicle stimulating protein (FSP) dry powder compositions for aerosolized delivery to the deep lung, methods of preparing and administering such compositions, and methods for treating infertility involving administering the dry powders by pulmonary delivery to the deep lung.

Pulmonary administration of dry powder formulations for treating infertility

The present invention provides highly dispersible spray-dried powder compositions, and in particular, inhaleable dry powder compositions for aerosolized delivery to the lungs. The powders of the invention are produced by spray drying a 4 &#x3b1;-helix bundle protein under conditions which both (i) protect the protein from aggregation and (ii) provide particles suitable for inhalation (i.e., demonstrating superior aerosol performance).

Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation

The present invention provides highly dispersible spray-dried powder compositions, and in particular, inhaleable dry powder compositions for aerosolized delivery to the lungs. The powders of the invention are produced by spray drying a 4 &agr;-helix bundle protein under conditions which both (i) protect the protein from aggregation and (ii) provide particles suitable for inhalation (i.e., demonstrating superior aerosol performance).

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San Jose, CA, United States of America

Hi-Shi Chiang