Amorepacific Corporation

Heung Soo Baek

Yung Hyup Joo

Song Seok Shin

Hong-Ju Shin

Ho Sik Rho

Jeong Hwan Kim

John Hwan Lee

Jon Hwan Lee

Chang Seok Lee

Mi Jin Park

Yongjin Kim

Soo Jeong Choi

Yong Jin Kim

Seo Young Kim

Young Ho Park

Yong Deog Hong

Hyung Jun Lim

Byoung Young Woo

Kyung Min Lim

Yeon Su Jeong

Se Jin Yoo

Hae Kwang Lee

Ok Sub Lee

Yu Jung Kim

Chang Geun Yi

Chang Man Park

Mi Hyun Oh

Mi Young Park

Jeong A Lee

Byeong Yung Woo

Jeong Ah Hwang

Duck Hoo Kim

Ih Soop Chang

In one aspect of the present specification, provided is a method for predicting a side effect of a whitening ingredient, the method comprising measuring at least one of i) the increase in toxicity according to long-term use of a whitening ingredient, ii) the difference between a concentration having whitening effect and a concentration having cell toxicity, and iii) the increase in sensitivity to the whitening ingredient according to ultraviolet pretreatment. In addition, the method has an effect of effectively predicting whether a side effect will occur if the whitening ingredient is used for a long time.

Method for predicting side effect of whitening ingredient

The present invention relates to a method for preparing a benzoic acid amide compound in a high yield by presenting a novel method for preparing a benzyl amine compound to be used as a reactant and delimiting the reaction condition of each step by using the same, and the method is economically advantageous since mass production is possible.

Method for preparing benzoic acid amide compound

Disclosed is a novel adamantine derivative compound, an isomer thereof, pharmaceutically acceptable salt thereof, prodrug thereof, hydrate thereof or a solvate thereof. Also disclosed is a method for preparing a novel adamantine derivative compound, an isomer thereof, pharmaceutically acceptable salt thereof, prodrug thereof, hydrate thereof or a solvate thereof. The novel adamantane derivative compound or the like has an excellent anti-androgenic effect.

Adamantane derivative compound

The present invention relates to a composition which can effectively control bacteria by containing meso-2,3-butanediol, which is an isomer of 2,3-butane diol, and has excellent antiseptic power even without containing a chemical antiseptic agent.

Composition containing meso-2,3-butanediol

Disclosed are a novel benzoic acid amide derivative compound, an isomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate thereof, or a solvate thereof. The novel compound and the like inhibit melanin production, prevent tyrosinase activity, and have an excellent skin whitening effect.

Benzoic acid amide compound

The present invention relates to a cosmetic composition containing a hydroxypyranone derivative compound as an active ingredient for promoting the differentiation of adipocytes. The composition according to the present invention has an effect of promoting the differentiation of adipocytes, and thus allows the differentiation of adipocyte in a skin layer, thereby increasing the skin volume or elasticity. Therefore, the composition of the present invention can be variously used as a cosmetic composition or a pharmaceutical composition in the field, such as skin damage.

Cosmetic composition containing hydroxy pyranone derivative compound for promoting differentiation of adipocytes

5-Adamantan-1-yl-N-(2,4-dihydroxybenzyl)-2,4-dimethoxybenzamide disclosed in the present disclosure lacks toxicity and can exhibit superior anti-inflammatory effect. It exhibits superior anti-inflammatory effect, for example, by inhibiting the production of one or more of NO and PGE2, by inhibiting the activity of one or more of the transcription factors NF-&#x3ba;B and AP-1 or by inhibiting proinflammatory cytokines such as IL-1&#x3b2;.

Composition for anti-inflammation containing 5-adamantan-1-yl-N-(2,4-dihydroxy-benzyl)-2,4-dimethoxy-benzamide

The present invention relates to a novel benzoic acid amide derivative compound, isomers thereof, pharmaceutically acceptable salts thereof, prodrugs thereof, hydrates thereof, or solvates thereof. The novel compound has excellent skin whitening effects.

The present invention provides hydroxamic acid derivatives represented by the formula, having antioxidation, collagen biosynthesis promotion and skin pore contraction effects, and a method for preparation thereof. Further, the present invention provides skin-care external compositions for preventing skin aging, containing said hydroxamic acid derivatives represented by the formula as an active ingredient.

Hydroxamic acid derivatives and the preparation method thereof

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Yongin-si, South Korea

Heung Soo Baek