Max-Planck-Gesellschaft Zur F&#xf6;rderung Der Wissenschaften E. V.

University of Virginia Patent Foundation

Freie Universitat Berlin

Heung Sik Hahm

Peter H Seeberger

Ku-Lung Hsu

Jeffrey W Brulet

Claney Lebev Pereira

Chakkumkal Anish

Sharavathi Guddehalli Parameswarappa

Benjamin Schumann

Peter Seeberger

Subramanian Govindan

Kevin Pagel

Johanna Hofmann

Emmanuel K Toroitich

Adam L Borne

Adam Herman Libby

Kun Yuan

Caroline Elise Franks

Tao Huang

Sulfonyl-triazole compounds and related sulfonyl-heterocycle compounds are described. The compounds can be used to identify reactive nucleophilic amino acid residues, such as reactive tyrosines and reactive lysines, in proteins and to modify the activity of proteins with reactive nucleophilic amino acid residues via the formation of protein adducts comprising a fragment of the compounds. Methods are also described for screening the compounds to identify ligands of proteins comprising a reactive lysine or a reactive tyrosine.

Sulfur-heterocycle exchange chemistry and uses thereof

The disclosure is directed to compounds of the formula (1A), (I)—(V) and others disclosed herein and uses of such compounds.

Compositions and uses thereof

The present invention relates to a method for determining in an expedient manner and with minimal sample consumption the structure of an unknown carbohydrate by using ion mobility-mass spectrometry (IM-MS) in negative ionization mode and fragmentation and a database containing structures of carbohydrates and/or of the fragments of the negative ions of carbohydrates, and for each of the structures of the target carbohydrates the collision cross section value and the mass-to-charge ratio value of the negative ion thereof, and for each of the structures of the fragments of the negative ions of the target carbohydrates the collision cross section value and the mass-to-charge ratio value of the fragment of the negative ion of the target carbohydrate.

Method for determining carbohydrates structure

The present invention relates to synthetic saccharides of general formula (I) that are related toserotype 8 capsular polysaccharide, conjugates thereof and the use of said saccharides and conjugates for raising a protective immune response in a human and/or animal host. Furthermore, the synthetic saccharide structures of general formula (I) are useful as marker in immunological assays for detection of antibodies againstbacteria.

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Charlottesville, VA, United States of America

Heung Sik Hahm