Dong-A Pharmaceutical Co., Ltd

Therasid Bioscience Inc.

Seoul National University

Dong-A St Co., Ltd.

Dong-A Pharm. Co., Ltd.

Heung Jae Kim

Moohi Yoo

Woo Young Kwak

Jong Pil Min

Soon Hoe Kim

Song-Hyen Choi

Ji Hye Lee

Mi-Kyung Kim

Jae Young Lee

Tae Hyun Yoon

Wooyoung Kwak

Chang Yell Shin

Moon-Ho Son

Sungki Seo

Seung Hyun Song

Eun Jung Kim

Kyung Kyun Kang

Soon-Hoe Kim

Sun Ki Chang

Hyun Joo Shim

Yu Na Chae

Hyung Ki Lee

Byung Jun Jang

Geun Gho Lim

Kyung Jin Park

Eun Kyoung Yang

Hae-Sun Kim

Jang Hyun Park

Hadong Kim

Gook Jun Ahn

Ji Myun Jang

Chae Lim Ryu

Hae Hum Jung

Jae-Sung Hwang

Han Kook Chung

The present disclosure relates to a 1-(4-benzyloxy-benzyl)-3-methyl-thiourea compound in crystalline forms A, B, C, or amorphous form, a method for preparing the compound in the crystalline or amorphous forms, and a use of the compound for preventing or treating a metabolic disease or inflammatory disease.

Polymorphs of 1-(4-benzyloxy-benzyl)-3-methyl-thiourea

The present disclosure relates to a method for preparing 1-(4-benzyloxy-benzyl)-3-methyl-thiourea and a method for preparing a novel stable crystalline form A of 1-(4-benzyloxy-benzyl)-3-methyl-thiourea.

Method for preparing novel crystalline forms of 1-(4-benzyloxy-benzyl)-3-methyl-thiourea

Disclosed are a novel oxazolidinone derivative exhibiting inhibitory activity against CETP, a preparation method thereof, and a pharmaceutical composition comprising the same. Exhibiting excellent inhibitory activity against CETP, the oxazolidinone derivative can be effectively applied to the prevention or treatment of various CETP enzyme activity- or HDL cholesterol level-related diseases such as dyslipidemia, atherosclerosis, and coronary heart disease.

Oxazolidinone derivative as CETP inhibitor, its preparation method, and pharmaceutical composition comprising the same

The present invention relates to an improved method for preparing dipeptidyl peptidase-IV inhibitor intermediates. The present invention is able to reduce preparation costs by using low cost reagents on reaction and is able to be used in mass production by improving yield.

Method for preparing dipeptidyl peptidase-IV inhibitor and intermediate

The present invention relates to an improved method for manufacturing dipeptidyl peptidase-IV inhibitor and intermediate. The present invention allows reduction of production costs by reacting low cost reagents, improves yield and is adaptable for mass production.

Method for manufacturing dipeptidyl peptidase-IV inhibitor and intermediate

The present invention relates to a pharmaceutical composition for the prevention and treatment of diabetes or obesity comprising as active ingredients a compound which inhibits the activity of dipeptidyl peptidase-IV (DPP-IV), a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof, and one or more other antidiabetic or antiobesity agents. The pharmaceutical composition exhibits excellent glucose tolerance and may be useful in the prevention and treatment of diabetes, obesity, and the like by effectively inhibiting blood glucose levels and reducing fat mass.

Pharmaceutical composition for prevention and treatment of diabetes or obesity comprising a compound that inhibits activity of dipeptidyl peptidase-IV, and other antidiabetic or antiobesity agents as active ingredients

The present invention provides a novel heterocyclic compound containing a beta-amino group, a method for preparing the same, and a pharmaceutical composition comprising the same heterocyclic compound or a pharmaceutically acceptable salt thereof as an active ingredient. The heterocyclic compound of the present invention exhibits excellent DPP-IV inhibitory activity and bioavailability and therefore can be useful for the prophylaxis or treatment of DPP-IV-related diseases such as diabetes or obesity.

DPP-IV inhibitor including beta-amino group, preparation method thereof and pharmaceutical composition containing the same for preventing and treating diabetes or obesity

Growing community of inventors

Seongnam-si, South Korea

Heung Jae Kim