Cell2in, Inc.

Korea University Research and Business Foundation

Snu Rdb Foundation

Heun Soo Kang

Hye Mi Kim

Ji Eun Song

Ki Hang Choi

Yong Hwan Kim

Myung Jin Kim

Ji Woong Shin

Gwang Mo Yang

Eui Man Jeong

Hye Won Kang

In-Gyu Kim

Myoung Jin Kim

The present invention relates to a method of improving the quality of therapeutic cells by real-time glutathione monitoring.

Method for improving quality of therapeutic cell through real-time glutathione measurement

The present invention provides a method of measuring the quality of therapeutic cells through real-time glutathione monitoring.

Method for measuring quality of therapeutic cell through real-time glutathione measurement

The present invention relates to a real-time fluorescence imaging sensor for measuring glutathione in cell organelles and a method for fabricating the same. More specifically, the present invention relates to a novel compound for measuring glutathione in cell organelles, a method for preparing the novel compound, a real-time fluorescence imaging sensor for measuring glutathione in cell organelles, which comprises the novel compound, a method for fabricating the imaging sensor, and a method of measuring glutathione in cell organelles by use of the imaging sensor. When the composition comprising the compound according to the present invention is used, it can measure the antioxidant activity of the organelle mitochondria or Golgi apparatus in living cells, particularly stem cells, and can screen highly active stem cells based on the results obtained by measuring the antioxidant activity of the cell organelle.

Real-time fluorescence imaging sensor for measuring glutathione in organelle and preparation method therefor

The present invention relates to a fluorescence sensor capable of real-time imaging for measuring a cellular thiol level. The present invention reveals that the fluorescence intensity of the fluorescent real-time SH group-tracer (FreSH-Tracer) of the present invention increases or decreases continuously, ratiometrically or reversibly depending on the thiol level in living cells, and thus can be usefully used as a biosensor which is remarkably susceptible to quantitative or qualitative real-time detection of the cellular thiol level in living cells.

Real-time imaging sensor for measuring cellular thiol level

Growing community of inventors

Gyeonggi-do, South Korea

Heun Soo Kang