Yuhan Corporation

Ckd Bio Corp.

Heui-Il Kang

Young-Ae Yoon

Jae-Gyu Kim

Hyouk-Woo Lee

Suk-Won Yoon

Byung-Nak Ahn

Myung-Hun Cha

Sun-Young Jang

Dong-Hoon Kim

Chan-Sun Park

Seok-Hee Han

Tae-Hee Han

Doo-Jin Kang

Heung-Mo Kang

Su-Hyun Kyong

Yun-Beom Ham

Choong-Hyun Lee

Hyun-Ho Choi

Young-Ae 502-1006 Munrae Hyundai 5Cha Apt Yoon

Hyouk-Woo 405-202 Jugong Greenvil Apt Lee

Myung-Hun 105-1601 Jugong Tteuranchae Apt Cha

Ryong Choi

The present invention relates to a novel process for preparing the aza cyclohexapeptide compound 1-[(4R,5S)-5-[(2-aminoethyl)amino]-N-(10,12-dimethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-pneumocandin B(caspofungin) represented by the following formula 1, which can improve the problem due to a pungent odor and toxicity during the process and can prepare caspofungin as a final product at high yield compared to conventional processes, and to novel intermediates which are used in the preparation process: 

Process for preparing caspofungin and novel intermediates thereof

The present invention provides novel pyrrolo[2,3-c]pyridine derivatives or pharmaceutically acceptable salts thereof, processes for the preparation thereof, and compositions comprising the same. The pyrrolo[2,3-c]pyridine derivatives or pharmaceutically acceptable salts thereof of the present invention have excellent proton pump inhibition effects and possess the ability to attain a reversible proton pump inhibitory effect.

Pyrrolo[2,3-c]pyridine derivatives and processes for the preparation thereof

The present invention provides novel pyrrolo[3,2-b]pyridine derivatives or pharmaceutically acceptable salts thereof, processes for the preparation thereof, and compositions comprising the same. The pyrrolo[3,2-b]pyridine derivatives or pharmaceutically acceptable salts thereof of the present invention have excellent proton pump inhibition effects and possess the ability to attain a reversible proton pump inhibitory effect.

Pyrrolo[3,2-B]pyridine derivatives and processes for the preparation thereof

The present invention provides novel pyrrolo[3,2-c]pyridine derivatives or pharmaceutically acceptable salts thereof, processes for the preparation thereof, and compositions comprising the same. The pyrrolo[3,2-c]pyridine derivatives or pharmaceutically acceptable salts thereof of the present invention have excellent proton pump inhibition effects and possess the ability to attain a reversible proton pump inhibitory effect.

Pyrrolo[3,2-c]pyridine derivatives and processes for the preparation thereof

Growing community of inventors

Gunpo-si, South Korea

Heui-Il Kang