University of Pittsburgh

Heth Turnquist

Stephen Francis Badylak

George S Hussey

Quan Liu

Jenna Lynn Dziki

Zhongqiang Zhang

Methods are disclosed for treating a subject with a disorder, such as, but not limited to, a) fibrosis of an organ or tissue; b) solid organ transplant rejection; or c) a cardiac disease that is not myocardial infarction or myocardial ischemia. These methods include selecting a subject having or at risk of having the disorder, and administering to the subject a therapeutically effective amount of isolated nanovesicles derived from an extracellular matrix, wherein the nanovesicles contain interleukin (IL)-33 and comprise lysyl oxidase, and wherein the nanovesicles a) do not express CD63 or CD81, or b) are CD63CD81. In additional embodiments, methods are disclosed for increasing myoblast differentiation.

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Pittsburgh, PA, United States of America

Heth Turnquist