Centre National De La Recherche Scientifique

Université Paris Descartes

Institut National De La Sante Et De La Recherche Medicale

The University of Chicago

Universite Claude Bernard – Lyon1

Université De Rennes 1

Université De Bretagne Occidentale

Centre Hospitalier Universitaire De Brest

Manros Therapeutics

Commissariat a L'energie Atomique Et Aux Energies Alternatives

The Rockefeller University

Université Claude Bernard Lyon I

Inserm (Institut National De La Sante Et De La Recherche Medicale)

Women & Infants Hospital of Rhode Island

Scientiam Pharma

Hervé Galons

Paul Greengard

Laurent Meijer

Nassima Oumata

Aloïse Mabondzo

Florence Popowycz

Benoit Joseph

Christian Berthou

Karima Bettayeb

Anne-Cécile Guyot

Deborah J Nelson

Barbara Stonestreet

Karine Lester

Narciso Costa

Aida Gabdoulkhakova

Marc Flajolet

Vladimir Riazanski

Alain Pruvost

Clémence Disdier

Deborah Nelson

Benoït Joseph

A method for treatment of disease by reduction in macrophages-mediated bacterial killing, including administration to patients in need a compound of formula (I): wherein A is N or CH; B is NO, or S; Ris H, (C-C)alkyl group, methyl(C-C)cycloalkyl group or (C-C)cycloalkyl group; Ris an aryl, arylmethyl group or methylheteroaryl group as methylpyridine and methylthiophene; Ris absent when B is O or S, or is H or (C-C)alkyl group when B is N; Ris (C-C)alkyl group or (C-C)cycloalkyl group, groups bearing a carboxylic acid group, and (C-C)alkyl group or (C-C)cycloalkyl substituted by hydroxyl group, halogen group or methoxy group, when B is N, Rand Rcan together form a 5- or 6-membered heterocycle substituted by carboxylic acid group, substituted by a halogen atom, hydroxyl group, methoxy group or hydroxymethyl group, or pharmaceutically acceptable salt. Also provided are new compounds relating to this use.

Purine derivative compounds for medical use

A compound of formula (I), or a pharmaceutically acceptable salt thereof, where Ris a (C-C)alkyl or (C-C)cycloalkyl group; Ris a (C-C)alkyl, (C-C)cycloalkyl, (C-C)alkenyl, (C-C)fluoroalkyl, (C-C)fluoroalkoxy, or (C-C)alkoxy(C-C)alkyl group, substituted: (i) with one to three hydroxyl groups, or (ii) with an NRRgroup, where Rand Rare independently a hydrogen atom or a (C-C)alkyl group; or a pyrrolidinylmethyl group substituted with one to three hydroxyl groups; Ris the same as Ror hydrogen; the Rand Rgroups independently being substitutable with an &#x2014;OCORgroup, where Ris a natural or unnatural amino acid derivative or a piperidyl group; alternatively, Rand Rtogether form a heterocyclic compound; X and Y are independently a substitutable phenyl or heteroaryl group, the heteroaryl group being a thienyl, pyridyl, pyrimidinyl, thiazolyl, pyrrolyl, or furanyl group; and Ris a hydrogen or a (C-C)alkyl group.

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At least one compound of following formula I: 

Use of purine derivatives for the manufacture of a medicament

Growing community of inventors

Paris, France

Hervé Galons