Universitè Catholique De Louvain

Biotransplant, Inc.

Hervé Bazin

Dominique Latinne

Pierre Gianello

Mary E White-Scharf

Ruth A Kaplan

Christina E Postema

Thomas Kieber-Emmons

A monoclonal antibody which binds to baboon and human CD2, and in particular LO-CD2b antibody. The antibody may be employed to prevent and inhibit an immune response in human patients, such as when the immune response is mediated by the activation and proliferation of T-cells or natural killer cells.

Method of treatment with anti-CD2 antibody LO-CD2b

The present invention relates to a LO-CD2a antibody and methods of using such antibodies or molecules that bind to the same epitope (or a portion thereof) to prevent and inhibit an immune response in human patients, preferably, where the immune response is mediated by the activation and proliferation of T cells or natural killer cells. The administration of an effective amount of the LO-CD2a antibody to a human patient will prevent or inhibit graft rejection, graft versus host disease or autoimmune disease.

LO-CD2a antibody and uses thereof for inhibiting T cell activation and proliferation

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Brussels, Belgium

Hervé Bazin