Cis Bio International

Cis Bio International French Joint Stock Company

Ion Beam Applications S.a.

Institut Gustave Roussy

Cisbio Bioassays

Hervé Bazin

Eric Trinquet

Gérard Mathis

Gerard Mathis

Norbert Tinel

Michel Fink

Laurent Lamarque

Emmanuel Bourrier

Fabrice Andre

Patrick Garnero

Iris Pribilla

Michel Laget

Hervé Ansanay

Sraboni Ghose

Herve Autiero

Joseph Marchand

The invention relates to compounds of formula (I'): in which A, L2, M and B are as defined in the description. These compounds are substrates of O6-alkylguanine-DNA alkyltransferase and mutants thereof.

Substrates of O6-alkylguanine-DNA alkyltransferase and mutants thereof

The invention relates to a quantitative non-microscopic method of detecting intracellular interactions between biomolecules in living cells, in response to a biological or pharmacological stimulation, by a time-resolved proximate energy transfer effect between two members of a fluorescence donor/acceptor pair.

Method for detecting intracellular interaction between biomolecules

The present invention relates to inositol phosphate derivatives, in which the inositol phosphate is substituted with one or two reactive groups G or one or two conjugated substances or molecules M, said reactive group(s) G or said substance(s) or molecule(s) M being linked to IP1 via a linkage group L, M being chosen from the following group: a tracer, an immunogen, a member of a binding partner pair, a solid support. Application: tools allowing the study of the inositol phosphate cycle and therefore, indirectly, the study of seven transmembrane domain receptors coupled to phospholipase C, receptors having a tyrosine kinase activity, and in general enzymes involved in the variations of the intracellular concentration of IP1.

Inositol-phosphate derivatives and method of detecting inositol-1-phosphate

The invention relates to a process for reducing the fluorescence quenching caused by the measuring medium, in a fluorescence assay for an analyte using at least one fluorescent label, characterized in that a fluorescent conjugate comprising an oligonucleotide bonded to a rare-earth metal cryptate is introduced into the measuring medium.

Method for reducing fluorescence quenching in bioassays

The invention relates to a process for reducing the fluorescence quenching caused by the measuring medium in a fluorescence assay, by introducing into said medium of rare earth metal cryptates which are not very sensitive to this fluorescence quenching, said rare earth metal cryptates comprising at least one pyridine radical which is substituted one or more times or unsubstituted. The invention also relates to novel rare earth metal cryptates which are not very sensitive to the fluorescence quenching caused by the measuring medium.

Rare earth metal cryptates which are not very sensitive to the fluorescence quenching

The invention relates to a homogeneous method for detecting and/or determining by fluorescence a chemical or physicochemical interaction in a measuring medium, in which a rare-earth metal cryptate comprising a substituent is used, characterized in that the variation of at least one fluorescence characteristic of the rare-earth metal cryptate, induced by the change in the physicochemical properties of the substituent resulting from said interaction, is measured.

Homogeneous detection and/or determination method for a chemical or physico-chemical interaction

Conjugates of an oligonucleotide/electronic conductor polymer with a

Growing community of inventors

Villeneuve les Avignon, France

Hervé Bazin