J. Craig Venter Institute

Novartis Vaccines & Diagnostics, Gmbh

Glaxosmithkline Biologicals Sa

Novartis Ag

Novartis Vaccines and Diagnostics Srl

J. Craig Venture Institute, Inc.

Herve Tettelin

Vega Masignani

Guido Grandi

Maria Scarselli

Claire M Fraser

Mariagrazia Pizza

Rino Rappuoli

Cesira Galeotti

John Telford

Vincenzo Scarlato

Erin Hickey

Giulio Ratti

Marirosa Mora

Jeremy Petersen

J Craig Venter

Nathalie Norais

Maria Rita Fontana

Laura Serino

Danilo Gomes Moriel

Francesco Berlanda Scorza

Craig Venter

Maria Rosa Mora

Giulo Ratti

Jeremy D Peterson

Craig Ventor

The invention provides proteins from group B() and group A(), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.

Nucleic acids and proteins from streptococcus groups A and B

Disclosed herein are various open reading frames from a strain ofresponsible for neonatal meningitis (MNEC), and a subset of these that is of particular interest for preparing compositions for immunizing against MNEC infections.

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The invention provides proteins from, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.

Disclosed herein are various open reading frames from a strain ofresponsible for neonatal meningitis (MNEC), and a subset of these that is of particular interest for preparing compositions for immunising against MNEC infections.

The invention provides proteins from group B streptococcus () and group A streptococcus (), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.

Nucleic acids and proteins fromgroups A and B

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Gaithersburg, MD, United States of America

Herve Tettelin