Biomerieux, Inc.

Centre National De La Recherche Scientifique

Commissariat &#xc0; L'&#xc9;nergie Atomique Et Aux &#xc9;nergies Alternatives

Commissariat a L'energie Atomique

Biomerieux Sa

Commissariat a L'energie Atomique Centre National De La Recherche Scientifique

Hervé Rostaing

Laurent Drazek

Frédéric Pinston

Patrick Broyer

Elodie Sollier

Michel Guy

Corine Fulchiron

Jérôme Blaze

Yves Fouillet

Patrick Pouteau

Jean-luc Achard

Agnès Dupont-Filliard

Marie-Hélène Charles

Christine Peponnet

Carole Vachon

Nadine Perrot

Jean Luc Achard

Laurent Veron

Sandrine Gicquel

Agnés Dupont-Fillard

Agnès Dupont-Fillard

An extraction system includes a support bar including a sample well, a reagent well, at least one washing well, and at least one protection and retention housing; a pipetting element removably mounted on the support bar and extending at least partially into the at least one protection and retention housing; and a filtering and transfer device configured to capture and accumulate microorganisms contained in the sample and transfer the captured and accumulated microorganisms, the filtering and transfer device being removably mounted on the support bar and extending at least partially into the at least one protection and retention housing. The filtering and transfer device includes a hollow body having an elongated shape and including a proximal end portion and a distal end portion; and a filtering element fixed to the distal end portion of the hollow body.

Extraction system and method for extracting microorganisms contained in a sample

A method for collecting microorganisms when contained in a fluid includes (i) introducing the fluid into a cavity of a collecting device via at least one admission duct, (ii) capturing the microorganisms when contained in the fluid with a set of beads retained in the cavity as the fluid passes through the set of beads, (iii) evacuating the fluid from the cavity via at least one evacuating duct, (iv) introducing a reaction liquid into the cavity via at least one admission channel, (v) collecting the microorganisms from the set of beads with the reaction liquid as the reaction liquid passes through the set of beads, and (vi) evacuating the reaction liquid from the cavity via at least one evacuating channel.

Automated system for the lysis of microorganisms present in a sample, for extraction and for purification of the nucleic acids of said microorganisms for purposes of analysis

A method for detecting a presence or an absence of at least one zone of inhibition, the method including a step consisting in depositing a volume of the sample in liquid form along a deposition zone extending along an axis at the surface of the agar culture medium and a step consisting in depositing a determined amount of a chemical agent at the surface of the agar culture medium, the deposit defining a potential zone of inhibition, the axis of the zone of deposition of the sample intersecting the potential zone of inhibition.

Method for detecting a presence or absence of at least one first zone of inhibition

The invention relates to a device for obtaining biological material and/or biological information from a sample with a heterogeneous matrix, to the uses of said device, to methods implementing said device, and to kits for obtaining biological material and/or biological information from a sample with a heterogeneous matrix, comprising the different constituents of said device.

Device for obtaining biological material and/or biological information from a sample with a heterogeneous matrix

A locating method and system of determining a microorganism concentration of a fluid in a Petri dish is disclosed. The Petri dish includes a culture medium on which a seeding device is rotatable relative to the Petri dish. The seeding device distributes the fluid and includes at least one point of contact with the culture medium. The point of contact is associated with a contact zone.

Means, method and computer program product for determining the concentration level of microorganisms during a fluid analysis

A device and method for collecting microorganisms from a fluid includes: a reaction module containing beads, fluid admission duct allowing entry into the module, fluid evacuating duct allowing outlet of the fluid passed through the module, retaining beads in the module, at least one channel for admission of reaction liquid, at least one channel for evacuation of the liquid(s), channels for admission and evacuation of the reaction liquid and the ducts for admission and evacuation of the fluid being positioned with: ducts for admission and evacuation of fluid facing and enclosing the module, in order to maximize contact between the fluid and beads, channels for the reaction liquid(s) being positioned respectively at opposite ends of the module, and channels for the reaction liquid(s) positioned in a plane, and ducts for admission and evacuation of fluid positioned along an axis, and in that the axis is roughly perpendicular to the plane.

The present invention relates to a device for preparation and/or treatment of a biological sample comprising a set of storage chambers and/or reaction chambers intended for receiving a fluid, the chambers being separated by walls so as to constitute a set of adjacent chambers. It also relates to an analysis apparatus capable of using such a device and also a method of using this device. The device comprises a base and a drawer comprising the set of adjacent chambers, the drawer being movable relative to the base, the drawer comprising a contact surface on which emerge first means for placing in fluidic communication linked to the volume of at least one chamber, the contact surface of the drawer being intended to be positioned facing a contact surface of the base comprising at least one position at which there are arranged second fluidic communication means linked to detection means. The invention has a preferred application in the field of medical diagnosis.

Device for preparing and/or treating a biological sample

A device for preparing biological samples including a fixed support of which the base extends in a first plane, a filtration block that can be removable, the filtration block including a collecting tank that itself includes a filtering device extending in a second plane and dividing the collecting tank into a collection area and a suction area, the suction area being designed to be connected to a suction device, the second plane of the filtering device being inclined relative to the plane of the base of the fixed support.

Device for preparing biological samples

Disclosed herein is a device for sampling blood by capillarity for separating a plasma phase of the blood from the cell phase. The device is a strip and includes a filter having a membrane with no clumping agents, a prefilter for spreading blood over the surface of the membrane; and an absorbent paper downstream from the filter. The membrane is dimensioned to cover only a part of the surface of the prefilter and the migration of blood by capillarity within the prefilter takes place essentially lengthwise relative to the strip before blood comes into contact with the membrane.

Blood sampling device comprising at least one filter

A device for extracting a liquid phase from a suspension, the device being characterized in that it comprises: a main duct for conveying a flow of said suspension, the duct being of a length that is sufficient to enable a layer of said suspension to develop that is depleted in solid phase; flow disturbance means for disturbing the flow of said suspension, said means being provided in the main duct and being adapted to cause at least one recirculation vortex to form so as to increase locally the thickness of said depleted layer; and liquid extraction means disposed in a region of the device where said suspension is enriched in liquid phase as a result of said recirculation vortex. A method of extracting a liquid phase from a suspension, the method comprising injecting said suspension into such a device at a flow rate suitable for causing at least one recirculation vortex to be formed, and extracting a fraction of said suspension that is enriched in liquid as a result of said vortex.

Device and a method for separating a suspension

A method of extracting a liquid phase from a suspension, the method comprising: injecting said suspension into a duct presenting a first section that is straight and a second section that is curved; and at the outlet from said curved section of the duct, extracting a liquid-enriched fraction of said suspension that is spatially separated from a particle-enriched fraction of the suspension; the method being characterized in that the injection flow rate of the suspension and the geometry of the duct are selected in such a manner that: in the straight section, lift forces cause particles to be superconcentrated in a ring around the longitudinal axis of the duct; and in the curved section, Dean secondary flows deform said ring and give rise to spatial separation between said liquid-enriched fraction and said particle-enriched fraction. A device for implementing such a method.

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Le Versoud, France

Hervé Rostaing