Centre National De La Recherche Scientifique

Université´ D'aix-marseille

Université Paul Cézanne Aix-marseille III

Stmicroelectronics R&d Limited

Université De Lille

Ecole Centrale De Marseille

Université D'aix-marseille (amu)

Universite Aix-marseille

Ecole Centrale De Marseille (ecm)

Centre National De La Recherche Scientifique-cnrs

Hervé Rigneault

Esben Ravn Andresen

Jeffrey M Raynor

Jérôme Charles Wenger

David Gachet

Sophie Brustlein

Pierre-Francois Lenne

Renaud Vincentelli

Siddarth Sivankutty

Thomas W Ebbesen

Pascal Berto

Mitchel O'Neal Perley

Viktor Tsvirkun

Olivier Vanvincq

Géraud Bouwmans

Hugues Giovannini

Nicolas Sandeau

Michaël Maurin

Evgueni Popov

Pierre-François Lenne

Mitchell O'Neal Perley

Michael Maurin

Franck Billard

Esben Andresen

Jérôme Wenger

Siddharth Sivankutty

According to one aspect, the invention relates to a device () for transporting and controlling light beams comprising a light guide () comprising a bundle () of uncoupled single-mode optical fibers (F), each single-mode optical fiber (F) being intended to receive an elementary light beam (B) at a proximal end and to emit a light beam (B) at a distal end, said bundle of single-mode optical fibers comprising, in operation, a minimum radius of curvature corresponding to a maximum curvature of the bundle of fibers. The device () furthermore comprises an optical device for phase controlling, said device being arranged on the side of the proximal end of the light guide () and comprising at least a first spatial light modulator () suitable for applying a phase shift to each of the elementary beams (B), and a control unit () for controlling the first spatial light modulator, said unit being configured to apply a phase shift to each of the elementary beams (B) so as to form, at the distal end of the light guide, an illumination beam with a predefined phase function. According to the present description, said bundle () of single-mode optical fibers is twisted, and comprises a twist period (P) defined to preserve said phase function at the distal end of the light guide when the bundle of single-mode optical fibers is subjected to a curvature lower than said maximum curvature.

Devices and methods for transporting and controlling light beams

According to one aspect, the invention relates to a device for transporting and controlling light beams for endo-microscopic imaging without a lens on the distal side comprising a single-mode optical fibre bundle () on the distal side, wherein each single-mode optical fibre is intended to receive an elementary light source and to emit a light beam at a distal end; a single-mode optical fibre section () arranged at the distal end of the optical fibre bundle and intended to receive the light beams emitted by the single-mode optical fibres of the optical fibre bundle; an optical phase control device arranged on the side of the proximal end of the single-mode optical fibres. The optical phase control device comprises at least one spatial light modulator () adapted to apply a phase shift to each of the elementary beams and control means () for controlling the spatial light modulator allowing application of a phase shift to each of the elementary beams to form an illumination beam with a determined phase function at the distal end of the multimode optical fibre section ().

Devices and methods for conveying and controlling light beams for lensless endo-microscopic imagery

According to one aspect, the invention concerns a device for transporting and controlling light pulses for lensless endo-microscopic imaging and comprises:

Device and method for controlling group velocity delays of pulses propagating in monomode optical fibers of a fiber bundle

A method for detecting the presence of an analyte () in a solution () comprising: providing at least a first and a second probes (A, B) different from each other, each probe (A,B) comprising a nanoparticle conjugated with a receptor specific to the analyte (); contacting the solution () suspected of including the analyte () with the first and the second probes (A, B) to form a sample solution (), wherein the sample solution () comprises aggregates () comprising the analyte () combined with the first and the second probes (A, B); illuminating the sample solution () with a light source having at least a first and a second exciting wavelengths (&#x3bb;, &#x3bb;) different from each other wherein the first and the second wavelength are chosen to get specific optical responses from the first probe (A) and the second probe (B) respectively when illuminated; detecting as a function of time the light scattered by the first probe (A) at a first detection wavelength (&#x3bb;) and the light scattered by the second probe (B) at a second detection wavelength (&#x3bb;) to get a first signal and a second signal respectively; and detecting temporal coincidences between said first signal and second signal.

Detection of analytes using nanoparticles as light scattering enhancers

According to one aspect, the invention relates to a device for detecting a resonant non-linear optical signal of Stimulated Raman Scattering (SRS) type induced in a sample. The device comprises electro-optical means for making interact in the sample, at a first modulation frequency, trains of light pulses of angular frequencies &#x3c9;and &#x3c9;and, at a second modulation frequency, trains of light pulses of angular frequencies &#x3c9;and &#x3c9;, such that &#x3c9;&#x2212;&#x3c9;=&#x3c9;&#x2212;&#x3c9;=&#x3a9;where &#x3a9;is a molecular vibrational resonant angular frequency of the sample. Moreover, the device comprises means for synchronous detection at the first and second modulation frequencies of non-linear optical signals resulting from the interaction of the light pulses in the sample, and electronic processing means making it possible to obtain, from electronic signals resulting from the synchronous detection, a signal characterizing the molecular vibrational resonance of the sample.

Device and method for stimulated Raman detection

A method and a device for detecting a resonant non-linear optical signal induced in a sample including a resonant medium and a non-resonant medium forming an interface is disclosed. The device includes an excitation light beam that intercepts the sample along an optical axis. The device further includes a first optical detection module for detecting a nonlinear optical signal resulting from the interaction of the beam with the sample, and a mirror that reflects the excitation beam. The device further includes a second optical detection module for detecting a nonlinear optical signal resulting from the interaction of the reflected excitation beam with the sample, and a processing module for processing the optical signals, detected by the first and second detection modules. Processing the optical signals includes calculating a difference in the detected signals, the difference being characteristic of a vibrational or electronic resonance of the resonant medium.

Method for detecting a resonant nonlinear optical signal and device for implementing said method

The disclosure relates to a pixel-type biological analysis device comprising a photosensitive layer, a capture mixture for the capture of targeted proteins, the capture mixture being placed on an external surface of the photosensitive layer and comprising a protein probe grafted to a hydrogel, collection means for collecting photoelectrons in the photosensitive layer, and reading and treatment means of an electrical quantity supplied by the collection means, for the supply of a characteristic value of a luminous intensity detected by the photosensitive layer.

Pixel-type biological analysis device, biosensor, and fabrication processes thereof

A method and device for detecting a resonant non-linear optical signal induced in a sample, the sample including a resonant medium and a non-resonant medium forming an interface. The device includes an emission source of at least one first excitation light beam, called a pump beam, at a given angular frequency &#x3c9;for the excitation of the resonant medium of said sample, an optical detection module for detecting a non-linear optical signal resulting from the interaction of said pump beam with an axial interface between the resonant and non-resonant media of the sample, in at least two symmetrical directions ({right arrow over (k)}, {right arrow over (k)}') relative to the optical axis of said excitation beam incident in the sample, and a processing unit for processing signals (I({right arrow over (k)}), I({right arrow over (k)}&#x2032;)) thus detected, allowing the difference between said signals to be obtained.

The invention relates to a device () for detecting the emission of a target particle () at an emission wavelength, said device comprising: a photo-detector (A,B) comprising a sensitive detection surface having a high optical index; wherein said target particle () can be positioned in the vicinity of said sensitive surface in an analysis medium () having a low optical index; said device being characterized in that it further comprises: a mask () covering said sensitive surface, said mask including at least one area () opaque at said emission wavelength and at least one hole (), said hole being capable of receiving the target particle; and in that the mask includes at least one interface;said device further comprising at least one groove (A,B) provided at said interface, each of said at least one groove surrounding each of said at least one hole.

Device for the exalted detection of the emission of a target particle

The disclosure relates to a fabrication process of a biosensor on a semiconductor wafer, comprising steps of: making a central photosensitive zone comprising at least one pixel-type biological analysis device comprising a photosensitive layer, and a first peripheral zone surrounding the central photosensitive zone, comprising electronic circuits. The first peripheral zone is covered by a hydrophilic coating, and the central photosensitive zone is covered with a hydrophobic coating. A barrier of a bio-compatible resin is formed on the second peripheral zone.

Fabrication process of a biosensor on a semiconductor substrate

The invention concerns a confocal microscope for imaging a sample comprising at least a light source, said microscope comprising at least an objective and a tube lens with an image focus, said microscope comprising interference means constructed to generate interference figures from said light source, characterized in that said interference means comprising first image generation means constructed to generate a first image of said light source, second image generation means constructed to generate a second image of said light source symmetrical to the first image relative to the image focus, image interference means constructed to make said first image and said second image interfere.

Interferometric confocal microscope

Growing community of inventors

Allauch, France

Hervé Rigneault