Aventis Pharma S.a.

Sanofi-aventis

Sanofi

Hervé Minoux

Jean-Marie Ruxer

Patrick Mailliet

Jean-Christophe Carry

Francois Clerc

Luc Bertin

Laurent Schio

Gilles Doerflinger

Fabienne Thompson

Maria Mendez-Perez

Marie-Pierre Cherrier

Fabienne Pilorge

Odile Angouillant-Boniface

Marcel Alasia

François Clerc

Claude E Barberis

Dominique Barbalat-Damour

Serge Mignani

Hans Matter

Stefanie Keil

Alain Commercon

Wolfgang Wendler

Matthias Urmann

Baptiste Ronan

Frank Halley

Arielle Genevois-Borella

Antony Bigot

Maike Glien

Bruno Filoche-Romme

Jacques Mauger

Anil Nair

Corinne Terrier

Maurice Brollo

Victor Certal

Karen Chandross

Patrick Bernardelli

Kirsten Bjergarde

Chantal Carrez

Cecile Combeau

Didier Benard

Bruno Filoche-Rommé

Lan Lee

Stephane Hourcade

Peter Hamley

Hélène Goulaouic

Nina Ma

Eric Parmantier

Thierry Gouyon

Yves Janin

Francois Vallee

Thierry Guyon

The disclosure relates to compounds of formula (I): wherein R, R, R, R, and Rare as defined in the disclosure, to the compositions containing them and to the use thereof as medicaments, in particular as anticancer agents. The disclosure also relates to the process for preparing the compounds of formula (I) and to reaction intermediates.

Pyrazolylbenzimidazole derivatives, compositions containing them and use thereof

The invention relates to the novel substances in Formula (I): wherein Het is a heterocycle optionally substituted by one or a plurality of radicals R1 or R'1; R is selected from the group comprising Formula (A&#x2032;), (B), (C), (D), or (E), with R1 and/or R&#x2032;1 selected from H, halogen, CF3, nitro, cyano, alkyl, hydroxyl, mercapto, amino, alkylamino, dialkylamino, alkoxy, phenylalcoxy, alkylhio, or carboxy that is free or esterified by an alkyl, carboxamide, CO&#x2014;NH(alkyl), CON(alkyl)2, NH&#x2014;CO-alkyl, sulfonamide, NH&#x2014;S02-alkyl, S(0)2-NHalkyl, or S(02)-N(alkyl)2 radical; all these radicals are optionally substituted; W1, W2, and W3 independently are CH or N; X is 0, S, NR2, C(O), S(O), or S(0)2; Z is optionally substituted H, Hal, -0-R2 or &#x2014;NH&#x2014;R2 with R2 being H, alkyl, cycloalkyl, or heterocycloalkyl; and these substances are all isomeric forms and salts thereof, used as drugs. 

HSP90 inhibitory carbazole derivatives, compositions containing same and use thereof

Pyrroloindoles of formula (I) are provided wherein Het is an aromatic or partially unsaturated, monocyclic or bicyclic heterocycle containing between 1 and 4 heteroatoms N, O or S, optionally substituted by R1 or R'1 which are the same or different; R is X-(A-B)n-CONH2, X-(A-B)n-O&#x2014;CONH2, X-(A-B)n-NH&#x2014;CONH2, X&#x2014;(CH2)m-heterocycloalkyl, X(CH2)m-aryl and X&#x2014;(CH2)m-heteroaryl wherein X is &#x2014;O&#x2014;C(O), &#x2014;NH&#x2014;C(O), NH&#x2014;CS, &#x2014;NH&#x2014;CO&#x2014;CH2-O&#x2014;; &#x2014;NH&#x2014;COCH2-S&#x2014;CH2-CO&#x2014;NH&#x2014;; &#x2014;NH&#x2014;CO&#x2014;(CH2)2-SO2-; and &#x2014;NH&#x2014;CO&#x2014;CH2-N(CH3)-CO&#x2014;; A and B are the same or different and are each independently a single bond, CH2, CH-alkyl, and CH-aralkyl; n=1, 2 and m=0, 1; R1 and/or R&#x2032;1 are H, halogen, CF3, nitro, cyano, alkyle, hydroxy, mercapto, amino, alkylamino, dialkylamino, alkoxy, alkylthio, and carboxy, free or esterified by an alkyl, carboxamide, CONH(alkyl), CON(alkyl)2, NH&#x2014;CO-alkyl, sulfonamide, NH&#x2014;SO2-alkyl, S(O)2-NHalkyl, and S(O2)-N(alkyl)2 group, all of said alkyl, alcoxy and alkylthio groups being optionally substituted themselves, said products being in all isomer forms and salts, as medicaments.

Derivatives of pyrroloindole which are inhibitors of Hsp90, compositions containing same, and use thereof

This invention relates to compounds of formula (I) to processes for the preparation of such compounds, to pharmaceutical compositions comprising such compounds, and to methods of treatment comprising administering of such compounds.

1,4-dihydropyridine-fused heterocycles, process for preparing the same, use and compositions containing them

The present invention relates to compounds of formula (I): wherein R1, R, R', L, Het, p and p&#x2032; are as defined herein, compositions containing them, and their use as medicinal products.

Fluorene derivatives, compositions containing the same and use thereof as inhibitors of the protein chaperone HSP 90

Compounds of formula (I), wherein R1 and R3 have the meanings given in the description, said compounds being in all isomeric forms; and salts thereof; processes for the preparation of the compounds and intermediates; compositions containing them, and the use thereof as medicaments, particularly as anti-cancer agents.

Substituted thieno[2,3-c]pyrazoles, process for preparing them, compositions containing them, and use thereof

The invention relates to phenyl-1,2,4-oxadiazolone derivatives with phenyl group and to their physiologically acceptable salts and physiologically functional derivatives showing PPARdelta agonist activity. What are described are compounds of the formula I, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparations. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistance is involved and demyelinating and other neurodegenerative disorders of the central and peripheral nervous system.

Phenyl-1,2,4-oxadiazolone derivatives with phenyl group, processes for their preparation and their use as pharmaceuticals

This invention relates to derivatives of 4-(benzimidazol-2-yl)fluorene and 4-(azabenzimidazol-2-yl)fluorene, to pharmaceutical compositions comprising such derivatives, and to methods of treatment of disorders related to Hsp90 protein activity, comprising administering such derivatives.

Fluorene derivatives, composition containing said derivatives and the use thereof

The present invention concerns hydrazinocarbonyl-thieno[2,3-]pyrazoles of formula (I): wherein R1, R3, R4, are R5 are as defined in the disclosure; their preparation method, compositions containing the same and their use for the treatment of pathological conditions, in particular as anticancer agents.

Hydrazinocarbonyl-thieno[2,3-C]pyrazoles, process for preparing them, compositions containing them and use thereof

The present invention relates in particular to novel chemical compounds, particularly to novel organophosphorus derivatives of indazoles, to the compositions containing them, and to the use thereof as medicinal products for treating cancers.

Organophosphorus derivatives of indazoles and use thereof as medicinal products

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Thiais, France

Hervé Minoux