Drugabuse Sciences, Inc.

L'oreal

UniversitÉ Paris Descartes

Université De Rennes 1

Centre Nationale De La Recherche Scientifique

Herve Galons

Philippe J Pouletty

Jean-Michel Scherrmann

Jean R Maignan

Laurent Meijer

Nassima Oumata

Karima Bettayeb

Luc Demange

Jallal Gnaim

The invention relates to trisubstituted or tetrasubstituted imidazo[4,5b]pyridines, to their uses as well as to a process for manufacturing them. The compounds of the invention are imidazo[4,5b]pyridines. The first general synthesis of 3,5,7 imidazo[4,5b]pyridines is disclosed in the description. The invention founds application, in particular, in the pharmaceutical field.

Perharidines as CDK inhibitors

The ethyl ester of derivatives of benzoyl ecgonine are provided having a linking group at the para position of the benzoyl group. The derivatives are used to bond to immunogenic polypeptides for production of antisera and monoclonal antibodies. The antisera and antibodies find use in assays, for treatment of cocaine overdose and detoxification.

Cocaethylene immunogens and antibodies

Mono (6-amino-6-deoxy)cyclodextrin derivatives substituted in the 6-position by an .alpha.-amino acid residue. These derivatives correspond to the following general formula: ##STR1## in which: CD represents .alpha.-, .beta.- or .gamma.-cyclodextrin,

mono(6-amino-6-deoxy)cyclodextrin derivatives substituted in the

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Paris, France

Herve Galons