Sidem Pharma

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Mitsubishi Tanabe Pharma Corporation

Sidem Pharma Sa

Hervé Ficheux

Suzy Charbit

Avraham Cohen

Michel Homerin

François Schutze

Francois Schutze

Alain Taccoen

Jean-Pierre Gesson

Martine Mondon

Frédéric Martinet

Nadia Fonteneau

Yoshio Inaba

The invention relates to enantiomer (&#x2212;) of tentoprazole. The inventive enantiomer (&#x2212;) of tenatoprazole, or (&#x2212;)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]imidazol[4,5-b]pyridine exhibits improved pharmacokinetic properties which make it possible to use a once a day posology of a drug for relevant indications. The enantiomer (&#x2212;) of tentoprazole can be used for treating digestive pathologies.

Enantiomer (-) of tenatoprazole and the therapeutic use thereof

The present invention relates to S-tenatoprazole monohydrated sodium salt, represented by the following formula and the use thereof in therapy for the treatment of digestive diseases.

Monohydrated sodium salt of S-tenatoprazole and the use thereof in therapy

The invention relates to enantiomer (&#x2212;) of tentoprazole. The inventive enantiomer (&#x2212;) of tenatoprazole, or (&#x2212;)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]imidazol[4,5-b]pyridine exhibits improved pharmacokinetic properties which make it possible to use a once a day posology of a drug for relevant indications. Said invention can be used for curing digestive pathologies.

The invention concerns novel flavone and isoflavone derivatives of formulae (Ia) and (Ib) wherein: X represents a group of formula &#x2014;COOR, or &#x2014;PO(OR); R represents a hydrogen atom or an alkaline or alkaline-earth metal, or a lower alkyl group; Rrepresents a hydroxy group, a lower alkoxy group or an acyloxy group; Rand R, identical or different, represent a hydrogen or halogen atom, or a trifluoromethyl group, a trichloromethyl group, a hydroxy group, an alkoxy group or an acyloxy group comprising 1 to 5 carbon atoms, or Rand Rcan combine to form an alkylene dioxy group. The invention is useful for rheumatic diseases.

7-carboxy-flavone derivatives preparation method and therapeutic use

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Nogent-Sur-Marne, France

Hervé Ficheux