Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Alza Corporation

Herve Bercovier

Yechezkel Barenholz

Shimon Gatt

Francis J Martin

Samuel Zalipsky

Martin C Woodle

Zvi Eldar

Ayelet Barenholz

Jonathan M Gershoni

The present invention is based on the discovery that biological peptide-based mimotopes of mannose-containing cell-wall compounds of, specifically, ManLAM, have an anti-inflammatory effect and immunoregulator effect in animal models of inflammation. Such models include animal models of allergic peritonitis, allergic asthma and septic shock model (mice injected with LPS) and in Crohn's disease model (TNBS-induced colitis). Thus, the present invention concerns the use a molecule, particularly, an amino acid based molecule for the production of a pharmaceutical composition for the treatment of an inflammatory condition, the amino acid comprising one or more peptides characterized in that it can bind to ManLAM binding antibodies; and/or it can elicit an immune response in a subject inoculated therewith, giving rise to production of ManLAM-binding antibodies. The invention also provides pharmaceutical compositions for treating inflammatory conditions and comprising the amino acid-based molecule, as well as to methods of treatment of such conditions by administering to a subject an amount of the amino-acid based molecules.

Use of mycobacterial mannosylated lipoglycans peptide mimotopes for treating inflammation

The present invention relates to the identification of antigenic and immunogenic peptide-based mimicry of mannose-containing cell-wall compounds characterizing mycobacterial infectious agents, such as Amino acid molecules which are mimotopes of mannosylated lipoglycans, such as lipoarabinomannan (ManLAM), including at least one of the following characteristics: (a) being capable of binding to ManLAM binding antibodies; (b) being capable of eliciting production of ManLAM binding antibodies, are provided. Also diagnostic methods for diagnosing mycobacterial infections and methods of vaccinating subjects against such infections. The diagnostic and vaccination methods employ the provided amino acid molecules. Accordingly, a diagnostic kit and a vaccine for executing the aforementioned methods are provided.

Peptide mimotopes of mycobacterial mannosylated lipoglycans and uses thereof

A liposome composition comprising small, surface-bound effector molecules is disclosed. The liposomes have a surface layer of hydrophilic polymer chains, for enhanced circulation time in the bloodstream. The effector molecules are attached to the distal ends of the polymer chains. In one embodiment, the effector is polymyxin B, for treatment of septic shock.

Enhanced circulation effector composition and method

The invention provides a moist, absorbent material for cleaning articles and surfaces, wherein the material is moistened with an aqueous solution containing liposomes having vesicles of a diameter of up to about 100 nm.

Moist, absorbent material for cleaning articles and surfaces

The invention provides a method for cleaning the surfaces of a motor vehicle which is contaminated with wastes containing organic or lipophilic deposits, comprising applying liposomes thereto, which liposomes modify the physical properties of the wastes to increase the polarity and wettability thereof.

Method for cleaning the surfaces of a motor vehicle

The invention provides a composition for enhancing the biodegradation of biodegradable organic wastes comprising a combination of organic-waste consuming microorganisms and liposomes wherein the liposomes supply essential nutrients for bacterial growth while concomitantly increasing the polarity and wettability of the waste, thereby increasing their availability for enhanced bacterial interaction therewith and methods for the use thereof.

Composition for enhancing the biodegradation of biodegradable organic

Method for enhancing the biodegradation of biodegradable organic wastes

The present invention provides a method for cleaning industrial and domestic surfaces and articles, as herein defined, which are contaminated with organic or lipophilic wastes, comprising applying liposomes thereto, which liposomes modify the physical properties of said wastes to increase the polarity and wettability thereof.

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Jerusalem, Israel

Herve Bercovier