Rhone-poulenc Rorer S.a.

Herv E Bouchard

Jean-Dominique Bourzat

Alain Commercon

Alain Commercedillaon

Jean-Pierre Pulicani

Taxoids having a 1,3-oxazole containing moiety at the 13-position of the taxane nucleus.

Taxoid intermediates

The invention relates to a process for preparing taxoids of formula I herein that includes the steps of esterifying a baccatin III derivative of the formula VI herein, acylating the compound obtained, and optionally removing a protecting group to give the desired taxoid product.

Process for preparing taxoids

New Baccatin III derivatives are disclosed for use in making taxoid compounds having formula (I) illustrated herein that exhibit antitumor activity.

Baccatin III derivatives

The invention relates to a process for preparing taxoids of formula I herein that includes comprising the steps of esterifying a baccatin III derivative of the formula VI herein, treating the compound obtained in acidic medium, and optionally removing a protecting group to give the desired taxoid product.

The invention relates to a process for preparing taxoids of formula I herein that includes the steps of esterifying a baccatin III derivative of the formula VI herein, treating the compound obtained in acidic medium, and optionally removing a protecting group to give the desired taxoid product.

New taxoids of general formula (I), their preparation and pharmaceutical compositions containing them. In general formula (I),

This invention relates to taxoids of general formula (I), their preparation and the pharmaceutical compositions which contain them. The products of general formula (I) have notable antitumoral properties. In the general formula (I),

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Ivry Sur Seine, France

Herv E Bouchard