Curis, Inc.

Creative Biomolecules, Inc.

Herrmann Oppermann

David C Rueger

Thangavel Kuberasampath

Charles M Cohen

Roy H L Pang

Engin Ozkaynak

John E Smart

Haimanti Dorai

The invention is a treatment for increasing the bone mass or preventing bone loss in an individual afflicted with a bone disease which includes administering to the individual a morphogen in a therapeutically effective amount so as to maintain or stimulate bone formation.

Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases

The present invention is a method for alleviating tissue destructive effects associated with the inflammatory response to tissue injury in a mammal. The method is particularly adapted to alleviating the tissue destructive effects associated with ischemia-reperfusion injury and hyperoxia injury.

Method for reducing extravasation of effector cells

Disclosed herein are improved methods and compositions for achieving enhanced protein production expressed from non-native gene constructs, including single chain sFv and derivative sequences. The methods and compositions are particularly useful for creating stably transfected, contitutively expressing immortalized mammalian cell lines that exhibit high recombinant protein productivity while maintaining a low copy number per cell of the non-native recombinant DNA sequence encoding the protein of interest.

Methods and compositions for high protein production from non-native DNA

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Medway, MA, United States of America

Herrmann Oppermann