Other

Magqu Co. Ltd.

Herng-Er Horng

Hong-Chang Yang

Shieh-Yueh Yang

Chin-Yih Rex Hong

Chau-Chung Wu

Kai-Wen Huang

Jen-Jie Chieh

Shu-Hsien Liao

Rex Chin-Yih Hong

Kai Chieh Yang

Rex Chih-Yih Hong

Wan-Sun Tse

Wai-Bong Yeung

Wai Bong Yeung

Multiplex immunoassays utilize the differential affinities among the conjugation pairs between the capture ligands and target analytes are proposed. Window magnetic-assisted rapid aptamer selection (window-MARAS) methods for selecting aptamers with desirable affinity toward the target analytes and methods for generating reagents for multiplex immunoassays or multiplex detection in one assay by utilizing the selected aptamers as capture ligands in reagents are described and used to demonstrate the feasibility of multiplex immunoassays based on the differential affinity of conjugation pairs between the capture ligands and target analytes.

Method of multiplex immunoassays utilizing differential affinity and methods for synthesizing aptamer-based reagents for multiplex immunoassays

A magnetism characteristic detection method, a magnetism characteristic detection apparatus, an imaging apparatus and an imaging method are provided, where magnetism detection and imaging are based on an integrated excitation field of a direct current (DC) magnetic field and an oscillation wave. The magnetism detection method includes the following steps. A DC magnetic field is selectively applied to an object. Further, an oscillation wave is provided to the object, where the oscillation wave is a sound wave or an ultrasound wave. Then, a magnetism characteristic variation of the object is detected.

Detection method, imaging method and related apparatus based on magnetism characteristic detection technique

The invention provides a low-field nuclear magnetic resonance system for measuring a magnetic resonance signal of an object. The low-field nuclear magnetic resonance system includes a pre-magnetization module, a uniform magnetic field coil module, a pulse and receiving coil module, a filter amplifier module, a signal acquisition module and a processing module. The pre-magnetization module is used to establish a pre-magnetization field in the object to increase magnetization of the object. The uniform magnetic field coil module is used to change a resonance frequency and background magnetic field intensity of the object during nuclear magnetic resonance measurement by regulating a magnetic field of the coil. The processing module further includes a programming object for controlling timing processing and signal analysis of the measurement process.

Low magnetic field resonance system

The invention provides a high resolution proton nuclear magnetic reonance and imaging (NMR/MRI) in microtesla magnetic fields by using high critical temperature (high-T) superconducting quantum interference device (SQUID) magnetometer via a flux transformer. Both the SQUID and the input coupling coil are installed inside a superconducting vessel which shields environmental noise and set the SQUID in a stable operation condition. The present invention also offers the advantages of preserving the NMR signal even if the sample is far away from the SQUID detector.

Squid detected nuclear magnetic resonance and imaging at ultra-weak fields

Disclosed is an apparatus for measuring ac magnetization at mixture frequency. The apparatus includes an ac generating unit for generating at least a first current with a frequency fand a second current with a frequency f. The apparatus further includes a co-axial solenoid unit, driven by the first and second ac currents, to generate a first magnetic field and a second magnetic field. A pick-up solenoid is for disposing sample for detecting an ac magnetization of the sample and multiple frequency-component signals corresponding to various frequency combinations of fand fare output. The apparatus further includes a signal processing circuit for receiving the frequency-component signals, where the signal processing circuit obtains the ac magnetization of the sample at a target frequency of (&#x3b3;f+&#x3b2;f), which &#x3b3;and &#x3b2;are positive integers and the frequency fand the frequency fare two different frequencies.

Device for measuring AC magnetization of materials

A method for suppressing non-specific bindings between molecules includes providing magnetic particles dispersed in a liquid, wherein each of the magnetic particles has a magnetization. The magnetic particles are coated with coating molecules. Binding molecules mixed of first-type binding molecules and second-type binding molecules are applied to the liquid, wherein the coating molecules are specifically binding with the first-type binding molecules and non-specifically binding with the second-type binding molecules. An alternating current (ac) magnetic field is applied at an axis with a frequency level, wherein the frequency level causes suppression of the second-type binding molecules in binding with the coating molecules.

Method and system for suppressing bindings on magnetic particles

An ultra-sensitive, wash-free method for quantitatively determining the concentration of biomolecules in a sample solution is provided. The sensitivity of the method is 1 ppt or below. The method includes providing a reagent containing magnetic nanoparticles and measuring the ac magnetic susceptibility of the reagent. Then, a sample solution containing either multiple-active epitope biomolecules or single-active-epitope biomolecules is mixed with the reagent. The ac magnetic susceptibility of the reagent after the association with the biomolecules is measured. Thereafter, the difference in the ac magnetic susceptibility of the reagent before and after the association with the biomolecules is measured and the concentration of biomolecules in the sample solution is determined.

Ultra-sensitive magnetoreduction measurement system and ultra-sensitive, wash-free assay using the same

The present invention provides a method for rapid detecting tumor. Moreover, this invention uses only the Tvalue as a parameter to distinguish tumor from normal tissue, and the accuracy of this detection is highly reliable.

Method for rapid detecting tumor

A method of examining cardiac electromagnetic activity over a heart for diagnosing the cardiac functions of the heart is disclosed. The method includes collecting a plurality of sets of spatially distributed, time-varying magnetic field signals of the heart of a subject, wherein the magnetic field signals exhibit features of at least a wave, identifying a time corresponding to a local maximum intensity of the magnetic field signals of the wave at each measurement position and plotting a temporal evolution of the local maximum intensity of the magnetic field signals during a time interval of the wave.

Method of examining dynamic cardiac electromagnetic activity and detection of cardiac functions using results thereof

A method of examining cardiac electromagnetic activity over a heart for diagnosing the cardiac functions of the heart is disclosed. The method may include constructing a phase diagram of electromagnetic signals over a heart by collecting sets of time-dependent magnetic signals, determining the zeroth and the first derivations of each set of the magnetic signals at a given time, and categorizing the zeroth and the first derivations of the magnetic signals in either of the four phases: (+, +), (&#x2212;, &#x2212;), (+, &#x2212;), (&#x2212;, +). The method may also include monitoring a wave propagation of the magnetic signals.

The present invention is directed to methods for quantitatively measuring biomolecules by using magnetic nanoparticles. Through the use of the magnetic nanoparticles and the bioprobes coated to the magnetic nanoparticles, the biomolecules conjugated with the bioprobes result in the formation of particle clusters. By measuring the changes in magnetic properties resulting from the existence of the bio-targets, the amount of the bio-targets in a sample to be tested can be measured.

Methods of quantitatively measuring biomolecules

A superconductive quantum interference device (SQUID) system is provided for measuring the alternating current (AC) magnetic susceptibility of material at a single frequency or a mixing frequency from multiple frequencies, such as mf+nf, where fand fare two excitation frequencies of two primary coils. The system includes a magnetic-flux sourcing unit for producing an AC magnetic flux on a sample and a magnetic-flux reading unit for reading the induced magnetic flux from the sample via a magnetic flux transformer. The magnetic-flux reading unit includes a SQUID set for detecting the induced magnetic flux, so as to obtain the magnetic susceptibility of the sample in converting calculation.

Superconductive quantum interference device (SQUID) system for measuring magnetic susceptibility of materials

A method for designing and tuning a refractive index of a magnetic fluid is performed by adjusting some characteristic parameters. The characteristic parameters include the type of carrier, the type of magnetic particles, the concentration of the magnetic ingredient; the wavelength of an intended light onto the magnetic fluid layer; the strength of applied magnetic field; the sweep rate of the magnetic field; the direction of the applied magnetic field; the strength of applied magnetic field associated with the thickness of the magnetic fluid layer; and the strength of applied magnetic field associated with the temperature. A magnetic fluid with a designed value of refractive index under zero magnetic field is synthesized by carefully selecting the carrier and the volume concentration of the magnetic particles, and this value can further be tuning around the designed value by changing the forgoing characteristic parameters.

Method for designing and tuning and system for measuring a refractive index of a magnetic fluid

The present invention comprises cyclotron display devices similar to cathode ray tubes (CRTs) in which the CRT electron gun is replaced by one or more cyclotrons that produce electrons using lower voltages and energy costs than a CRT electron gun does. This can be done both with monochrome and color displays, as disclosed. In addition, the electrons emerge from the cyclotron with adequate velocity, thus obviating the need for accelerating electrodes. The need for electron focusing is also greatly reduced, or eliminated, since the electrons emerge from the cyclotrons as beams, rather than as diffuse clouds. The cyclotron display assembly can be made to be significantly shorter than the conventional electron gun CRT. In addition, an array of cyclotrons, rather than just a single one, can be used, so that each cyclotron maps to a fractional portion of the video screen. This further shortens the length of the cyclotron display.

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Taipei, Taiwan

Herng-Er Horng