Nantbio, Inc.

Nant Holdingsip, LLC

Nantomics, LLC

Hermes J Garban

Kayvan R Niazi

Clifford Anders Olson

Shiho Tanaka

Shahrooz Rabizadeh

Stephen Charles Benz

Kamil A Wnuk

Raymond Wong

Chad Garner

Kevin B Givechian

Heather McFarlane

Helty Adisetiyo

Mark Guido

Tan Trinh

An immune gene expression signature is associated with favorable clinical features in Treg-enriched tumor samples and can be used to predict immunogenicity of a tumor, overall survival, and/or chemosensitivity.

Method of characterizing a tumor based on an immune gene expression signature in regulatory T cell (Treg)-enriched tumor samples

Antibodies, fragments thereof, and chimeric proteins comprising the same are presented that have specific binding activity against T-cell immunoglobulin mucin receptor 3 (TIM3). Advantageously, contemplated molecules can be used in pharmaceutical compositions for immune therapy, particularly in individuals receiving cancer vaccines and/or checkpoint inhibitor treatment.

Anti-TIM3 monoclonal antibodies and chimeric antigen receptors

Antibodies, fragments thereof, and chimeric proteins comprising same are presented that have specific binding activity against CD30. Advantageously, contemplated molecules can be used in pharmaceutical compositions for immune therapy, particularly in individuals diagnosed with hematopoietic malignancies, including Hodgkin lymphoma, CD30-positive B cell lymphomas, CD30-positive T cell lymphomas, CD30-positive NK cell lymphomas.

Anti-CD30 monoclonal antibodies and chimeric antigen receptors

Antibodies, fragments thereof, and chimeric proteins comprising same are presented that have specific binding activity against T-cell immunoglobulin mucin receptor 3 (TIM3). Advantageously, contemplated molecules can be used in pharmaceutical compositions for immune therapy, particularly in individuals receiving cancer vaccines and/or checkpoint inhibitor treatment.

Method of treating a tumor in a patient based on an immune gene expression

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Culver City, CA, United States of America

Hermes J Garban