Hoechst Aktiengesellschaft

Hermann Teufel

Wilhelm Bartmann

Gerhard Beck

Ernold Granzer

Josef Musil

Bernward Scholkens

Ulrich Lerch

Rudolf Kunstmann

Dieter-Bernd Reuschling

Klaus Kuhlein

Karl Seeger

Milos Babej

The present invention relates to thienyl-prostaglandin derivatives and to a process for their manufacture. The compounds according to the invention have valuable pharmaceutical properties.

Thienyl-prostaglandins and process for their manufacture

What is disclosed are prostaglandin-analogous cyclopentane derivatives of the formula I ##STR1## wherein R.sup.1 is hydrogen or a linear or branched, saturated or unsaturated aliphatic or cycloaliphatic radical having from 1 to 8 carbon atoms, or an araliphatic radical having from 7 to 9 carbon atoms, or a physiologically tolerable metal, NH.sub.4 or substituted ammonium ion derived from a primary, secondary or tertiary amine;

Novel prostaglandin derivatives

The present invention relates to pyrrolidones which are analogues of prostaglandins and to a process for their manufacture. The compounds of the invention have prostaglandin-like pharmacological properties and can therefore be used as pharmaceutical compositions.

Certain pyrrolidone derivatives and pharmaceutical use thereof

The present invention relates to analogues of prostanoic acids of the formula I ##STR1## their physiologically acceptable salts with organic and inorganic bases, their esters with aliphatic, cycloaliphatic or araliphatic alcohols and to a process for the manufacture of these compounds. The compounds according to the invention have valuable pharmacological properties and can be used as medicaments.

Analogues of prostaglandins

The invention relates to derivatives of 1,2-diarylethylene and to a process for their preparation. The compounds have valuable pharmaceutical properties and may be used as medicaments.

Derivatives of the 1,2-diarylethylene and pharmaceutical compositions

A medicament consisting of or containing an O-acyl-2,3-diaryl-3-halogeno-acrylaldoxime of the formula I ##STR1## in which X represents a chlorine or bromine atom, R stands for an alkyl, alkenyl, alkoxy, alkenoxy or alkylamino group having from 1 to 12 carbon atoms each, or for an aryl, aryloxy, arylalkyl, arylalkoxy, arylamino or arylalkylamino group substituted optionally by 1 or 2 alkyl groups each having from 1 to 6 carbon atoms, and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are identical or different, each representing a hydrogen atom, a halogen atom or an alkyl or alkoxy group having each from 1 to 6 carbon atoms, a process for preparing them and a method for the treatment of disorders of the purine metabolism.

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Kelkheim (Taunus), Germany

Hermann Teufel