Universitat Innsbruck

Université D'angers

Friedrich-Schiller-Universitat Jena

Schwaiger, Stefan

Stuppner, Hermann

Laufer, Günther

Bernhard, David

Hermann Stuppner

Stefan Schwaiger

David Bernhard

Günther Laufer

Pascal Richomme

Jean-Jacques Helesbeux

Oliver Werz

David Guilet

Denis Seraphin

Andreas Koeberle

Birgit Waltenberger

Daniela Schuster

Veronika Sophie Temml

The present invention relates to compounds of formula (III) or to compounds of formula (IV) 

Tocotrienol derivatives, pharmaceutical composition and method of use in 5-lipoxygenase related diseases

The present invention relates to a pharmaceutical composition comprising specific compounds which may be obtained fromCass. (Edelweiss). A preferred compound is leoligin (=(2S,3R,4R)-4-(3,4-dimethoxybenzyl)-2-(3,4-dimethoxyphenyl)tetrahydrofuran-3-yl]methyl(2Z)-2-methylbut-2-enoat]). Corresponding means and methods in respect of medical uses of the compounds are described. The present invention also provides a medical device comprising, containing or having been contacted with the compound. The compounds provided herein may particularly be used in the treatment of hyperplastic diseases, in particular intimal hyperplasia, e.g. stenosis, restenosis, atherosclerosis and the like. Also envisaged herein is the use of these compounds in the treatment of proliferative diseases, such as leukemia, prostate cancer and lung cancer.

Pharmaceutical compositions comprising lignans and their derivatives for treating hyperplastic diseases

The present invention relates to a pharmaceutical composition comprising specific compounds which may be obtained fromCass. (Edelweiss). A preferred compound is leoligin (=(2S,3R,4R)-4-(3,4-dimethoxybenzyl) -2-(3,4-dimethoxyphenyl)tetrahydrofuran-3-yl]methyl(2Z)-2-methylbut-2-enoat]). Corresponding means and methods in respect of medical uses of the compounds are described. The present invention also provides a medical device comprising, containing or having been contacted with the compound. The compounds provided herein may particularly be used in the treatment of hyperplastic diseases, in particular intimal hyperplasia, e.g. stenosis, restenosis, atherosclerosis and the like. Also envisaged herein is the use of these compounds in the treatment of proliferative diseases, such as leukemia, prostate cancer and lung cancer.

Growing community of inventors

Götzens, Austria

Hermann Stuppner