Consortium Fur Elektrochemische Industrie Gmbh

Wacker-chemie Gmbh

Wacker Chemie Ag

Consortium F&uuml;r Elektrochemische Industrie Gmbh

Rfs Pharma LLC

Consortium Für Elektrochemische Industrie Gmbh & Co. Kg

Hermann Petersen

Klas Sorger

Juergen Stohrer

Gerald Fleischmann

Jürgen Stohrer

Klaus Kohlhammer

Walter Dobler

Benno Krueger

Herbert Eck

Elke Fritz-Langhals

J&uuml;rgen Stohrer

Alfred Popp

Jodoca Rockinger-Mechlem

Siegfried Pflaum

Wolfgang Doering

Klaus Sorger

Wolfgang Döring

Andreas Boehm

Andrea Gilch

Benno Krüger

The invention relates to a process for preparing chloroacetaldehyde acetals of monohydric, dihydric or higher-functionality aliphatic alcohols, in which the chloroacetaldehyde acetal is obtained from an aqueous chloroacetaldehyde solution in the presence of the alcohol to be acetalized and an acid catalyst by azeotropic removal of water with the aid of a solvent, wherein the solvent is a halogenated solvent.

Process for preparing chloroacetaldehyde acetals

A process for preparing hydroxytyrosol, wherein a compound where X is CHOH or CHOM (M=Li, Na, K, Mg, Ca), Rand Rare identical or different and are C1-C8 alkyl radical, benzyl radical, alkyl- or halogen-substituted benzyl radical or arylalkyl radical, where Rand Rcan also be linked via to give a ring, R, R, Rand Rare identical or different and are hydrogen or C1-C6 alkyl radical, aryl radical, alkyl-substituted aryl radical, where Rand Rcan also be linked via &#x2014;(CH)&#x2014;, &#x2014;(CH)&#x2014; or &#x2014;(CH)&#x2014; to give a ring, is reacted with an aluminum compound AlRRR(2), where R, Rand Rare identical or different and are H or C1-C8 alkyl radical, and then an aqueous solution of a hydroxycarboxylic acid is added to form a clear homogeneous acidic solution with a pH&#x3c;3, and hydroxytyrosol is extracted therefrom.

Process for the preparation of hydroxytyrosol

Glycosylation of 2,6-diaminopurines or silyl derivatives thereof with a compound of the structure is facilitated by the presence of an optionally silylated 1,3-dicarbonyl compound during glycosylation. Byproducts are minimized, while stereoselectivity may be altered by choice of Lewis acid and other reaction condictions.

Method for the production of OH protected[4-(2.6-diamino-9H-purine-9-yl)-1.3-dioxolane-2-yl]methanol derivatives

The invention relates to a novel process for hydroxymethylating noncyclic &#x3b1;,&#x3b1;-dialkylcarboxylic acid derivatives with formaldehyde using amide bases at temperatures of from &#x2212;40&#xb0; C. up to the boiling point of the solvent or solvent mixture used.

Process for preparing &#x3b1;, &#x3b1;-dialkyl-&#x3b1;-hydroxymethyl-carboxylic acid derivatives

A process is provided for preparing optically active alcohols, amines and derivatives thereof by reacting aldehydes or imines at a temperature of less than 15&#xb0; C. in the presence of a chiral, enantiomerically pure auxiliary with an organozinc halide which is obtained from zinc and a reactive halogen compound, and water, acid or base, or an alkylating, arylating, acylating or silylating reagent is subsequently added.

Enantioselective reformatsky process for preparing optically active alcohols, amines and derivatives thereof

A process for removing zinc from organic solutions comprising zinc alkoxides or zinc amides, includes admixing the solution with an alkylating, arylating, acylating or silylating agent in the presence of a precipitating reagent having at least two nitrogen donors and subsequently removing the precipitated solid.

Removal of zinc salts from nonaqueous synthesis solutions comprising zinc alkoxides or zinc amides

A process is provided for preparing an enantiopure 1,3-dioxolan-4-one or 1,3-oxathiolan-5-one derivative, which includes bringing a mixture containing enantiomeric 1,3-dioxolan-4-one or 1,3-oxathiolan-5-one derivatives and an enzyme with hydrolytic activity into contact in the presence of a nucleophile. Cleaving a dioxolanone/oxathiolanone ring of one enantiomer occurs by the enzyme with hydrolytic activity and, after the cleavage of one enantiomer has taken place, the uncleaved enantiomer of the 1,3-dioxolan-4-one or 1,3-oxathiolan-5-one derivative is isolated.

Process for the enzymatic preparation of enantiopure 1, 3-dioxolan-4-one and 1,3-oxathiolan-5-one derivatives

An alcohol is oxidized to an aldehyde or a ketone in the presence of a nitroxyl compound as catalyst, wherein the alcohol to be oxidized is contained in an organic liquid phase, and is reacted in the presence of a nitroxyl compound with an aqueous phase comprising an oxidant. The reaction is carried out continuously at a contact time of the phases of from 0.1 s to a maximum of 15 minutes, with intensive mixing of the phases. The process produces high yields with low quantities of other oxidation byproducts.

Process for the oxidation of alcohols to aldehydes and ketones in the presence of nitroxyl compounds as catalysts

A process for the preparation of hydroxy and amino compounds, in which, in a first step, an aldehyde, ketone or imine is reacted in a Reformatsky reaction with a reactive halogen compound and zinc, in carboxylic esters as solvents, the reactive halogen compound being brought into contact with the zinc at the same time as or after contact with the aldehyde, ketone or imine, and in a second step, the reaction product of the first step is hydrolyzed.

Process for the preparation of hydroxy and amino compounds

A process for preparing organozinc halides in solvents, includes reacting a reactive halogen compound with zinc in one or more carboxylic esters. It is also possible to prepare keto, hydroxyl and amino compounds of organozinc halides obtained in a first step from a reactive halogen compound and zinc in one or more carboxylic esters, wherein the organozinc halide obtained is reacted in a second step with an electrophilic reaction partner and the reaction product of the second step is hydrolyzed in a third step.

Preparation of organozinc halides from reactive halogen compounds and their use

Process for the preparation of carbonyl compounds by cleavage of hydroxycarboxylic acids

The invention relates to a process for preparing ketene acetals by dehydrohalogenation of 2-haloaldehyde acetals. If the 2-haloaldehyde acetal is open chain, the dehydrohalogenation is carried out in the presence of an alkali metal hydroxide or alkaline earth metal hydroxide and a phase transfer catalyst and/or a secondary or tertiary alcohol or a secondary or tertiary diol. If the 2-haloaldehyde acetals is cyclic, the dehydrohalogenation is carried out in the presence of an alkali metal hydroxide or alkaline earth metal hydroxide and a phase transfer catalyst and with or without a secondary or tertiary alcohol or a secondary or tertiary diol, or carried out in the presence of an alkali metal hydroxide or alkaline earth metal hydroxide and a secondary or tertiary diol. The ketene acetals which can be prepared by the process of the invention serve as intermediates in organic synthesis and are suitable as monomers or comonomers in free radical polymerization for the production of biodegradable plastics.

Process for preparing ketene acetals

Graft copolymers having improved phase binding between the graft base and the grafted-on polymer, are prepared from:

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Burghausen, Germany

Hermann Petersen