Schering Aktiengesellschaft

Hermann Kunzer

Rolf Bohlmann

Yukishige Nishino

Martin Schneider

Karsten Parczyk

Gerhard Sauer

Helmut Hofmeister

Rosemarie Lichtner

Nikolaus Heinrich

Dieter Bittler

Josef Heindl

Christa Hegele-Hartung

Rudolf Wiechert

Ludwig Zorn

Karl-Heinrich Fritzemeier

David A Henderson

Monika Lessl

Jorg Kroll

Joseph Heindl

Hans-Peter Muhn-Seipoldy

11&bgr;-HALOGEN-7&agr;-SUBSTITUTED ESTRATRIENES, PROCESS FOR THE PRODUCTION OF PHARMACEUTICAL PREPARATIONS THAT CONTAIN THESE 11&bgr;-HALOGEN-7&agr;-SUBSTITUTED ESTRATRIENES AS WELL AS THEIR USE FOR THE PRODUCTION OF PHARMACEUTICAL AGENTS

This invention describes new, substituted 7.alpha.-(.xi.-aminoalkyl)-estratrienes of general formula I ##STR1## in which side chain SK is a radical of partial formula ##STR2## as well as their physiologically compatible addition salts with organic and inorganic acids. The new compounds represent compounds with very strong antiestrogenic action. The compounds according to the invention are, on the one hand, pure antiestrogens, or, on the other hand, antiestrogens with estrogenic partial action. Based on this spectrum of action, the new compounds are highly suitable for the production of pharmaceutical agents for tumor therapy and hormone replacement treatment.

7.alpha.-(.xi.-aminoalkyl)-estratrienes, process for their production,

This invention describes the new triphenylethylenes of general formula I ##STR1## in which n means an integer from 1 to 10,

Triphenylethylenes, process for their production, pharmaceutical

11.beta.-substituted 14,17-ethanoestratrienes, process for their

Disclosed are novel 14,17.alpha.-etheno- and -ethanoestratrienes according to general Formula I ##STR1## wherein X is a --CH.sub.2 --CH.sub.2 or ##STR2## R.sup.1 is a hydrogen atom, a C.sub.1 - to C.sub.15 -acyl, benzoyl, C.sub.1 - to C.sub.15 -alkyl, C.sub.3 - to C.sub.9 -cycloalkyl or alkylcycloalkyl group, and

14,17.alpha.-etheno- and -ethanoestratrienes, processes for the

Growing community of inventors

Berlin, Germany

Hermann Kunzer