Hoffmann-La Roche Inc.

Hermann Bretschneider

Marc Montavon

Armin Walser

Karl Bernauer

Janos Borgulya

Joseph Hellerbach

Urs Brombacher

Werner Rudolph

Gunther Bader

August Lutz

Gunter Weis

Wilhelm Klotzer

Kraft Hohenlohe-Oehringen

Joachim Schantl

Wolfgang Turk

Acridanone derivatives of the formula ##STR1## wherein the dotted line is an optional bond, R.sup.1 is hydrogen, halogen or nitro, R.sup.2 is hydrogen or lower alkyl, one of the substituents R.sup.3 and R.sup.4 is hydrogen or lower alkyl and the other together with R is an additional bond and R.sup.5 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl or lower alkyl substituted by halogen or lower alkoxy, and pharmaceutically acceptable acid addition salts thereof, processes for their preparation and pharmaceutical compositions based thereon, are described. The compounds of formula I are useful as schistosomicidal agents.

Schistosomicidal acridanone hydrazones

3-Methyl-N-(1-pyrrolin-2-yl)-pyrazole-5-carboxamides and processes for making same. Such compounds lower blood sugar and, hence, are useful as antidiabetic agents.

Pyrazole-5-carboxamides

The present disclosure relates to intermediates 2,2,3-endo-trimethyl-7-anti-amino-norbornanes and N-substituted analogs thereof. In particular the aforesaid compounds have a conventional protective group on the amino moiety and also hydroxymethyl or p-toluenesulfonyl oxymethyl groups in the 3-position.

Intermediates for preparation of

1,4-Benzodiazepin-2-ones bearing an acylamidoalkyl-substituent in the 1-position and methods for the preparation thereof are disclosed. These 1,4-benzodiazepin-2-ones exhibit sedative, anti-convulsant and muscle relaxant activity.

Process for preparing alkyl (n-phenylsulfonyloxy) carbamates

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Innsbruck, both of, undefined

Hermann Bretschneider