Byk Gulden Lomberg Chemische Fabrik Gmbh

Hermann Amschler

Wolf-Rudiger Ulrich

Kurt Klemm

Christian Schudt

Gerhard Ludwig

Benzofuran-4-carboxamides

Imidazopyridines

Fluoroalkoxy-substituted benzamides and their use as cyclic nucleotide

Pyridazines

Arylpyridazinones

6-aryl-3-cyanaminopyridazines, their preparation and use and medicaments

Pyridazinones, their preparation and use, and bronchospasmolytic

6-aryl-3[2H]pyridazinones of formula I ##STR1## in which one of the substituents R1 and R2 denotes hydrogen or (C1-C4)-alkoxy, and the other denotes polyfluoro-(C1-C4)-alkoxy, and their pharmacologically-tolerated salts are suitable as bronchospasmolytic and cardiotonic active compounds. Processes for their preparation and appropriate medicaments are indicated.

6-(polyfluoroalkoxyphenyl) pyridazinones, their compositions, synthesis

Substituted pyridazines of formula I ##STR1## wherein A denotes a lower alkylene group,

3,6-Disubstituted-5,7-(lower

A combination of urapidil and furosemide, e.g., in the form of an acid-addition salt, in the form of a physical admixture or in the form of two distinct components collectively constitutes an effective active ingredient in the treatment of hypertension. The combination is advantageously incorporated in a standard dosage form and administered by various routes to mammals afflicted with high blood pressure. By combining furosemide with urapidil on one of the noted forms, the maximum hypotensive activity of urapidil is increased, while the side effects and toxicity of urapidil are reduced.

Urapidil/furosemide compounds, compositions and use

Physiologically-active and pharmaceutically-acceptable 4-aminopyrazoles of each of the formulae ##STR1## wherein each of R.sup.1, R.sup.2 and R.sup.3 is, independently, e.g., a hydrogen atom (--H), aliphatic hydrocarbyl, alicyclic hydrocarbyl, phenyl, substituted phenyl, phenalkyl or nuclearly-substituted phenalkyl. And their pharmacologically-acceptable acid-addition salts are synthesized by known procedures from available starting materials or from compounds which are made by analogy procedures from known compounds. The subject 4-aminopyrazoles and their pharmacologically-acceptable acid-addition salts are prepared in the form of medicament compositions and used as diuretics, saluretics and/or antihypertensives.

4-(2-Imidazolin-2-yl) aminopyrazoles

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Radolfzell, Germany

Hermann Amschler