Other

The General Hospital Corporation

Genentech, Inc.

The State University of New York

Herman K Gold

A Mark Colb

Barry S Coller

Ralph H Schwall

Stuart Bunting

Robert C Leinbach

Desire Collen

Endothelialization of vascular surfaces. According to one aspect, the invention involves a technique for re-endothelializing an artery whose endothelial layer has been damaged by balloon angioplasty. The technique comprises, in one embodiment, introducing into the bloodstream of a patient, prior to performing the angioplasty, a quantity of a bispecific antibody, the bispecific antibody having a first antigen binding site directed against a surface marker common to both endothelial progenitor cells (EPCs) and endothelial cells (ECs) and having a second antigen binding site directed against a subendothelial epitope. The bispecific antibody is introduced in a quantity sufficient to bind a substantial percentage of circulating EPCs and circulating ECs. In this manner, once the angioplasty has been performed and the target epitopes on the subendothelium have been exposed, the bispecific antibodies that have already become bound to the circulating EPCs and ECs also then bind to the subendothelium. Thus seeded by the bound EPCs and ECs, the exposed subendothelium is covered after a short period of proliferation and differentiation.

Endothelialization of vascular surfaces

Methods for treating vascular stenosis using hepatocyte growth factor ('HGF') are provided. In the methods, HGF can be administered to enhance re-surfacing of blood vessels damaged or traumatized, for instance, by vascular surgery or angioplasty. Articles of manufacture and kits containing HGF are also provided.

Methods and compositions for treating vascular stenosis

The present invention relates to a novel treatment for myocardial infarction which comprises administering a hapten-binding molecule capable of preventing reformation of fibrin-platelet clots and a thrombolytic agent capable of either dissolving fibrin-platelet clots or inhibiting their formation. The therapy of the invention is capable of increasing clot lysis while minimizing fibrinogen breakdown and preventing the reocclusion of the affected coronary artery. The therapy of the present invention is capable of achieving this goal even in the absence of heparin and when the concentration of thrombolytic agent is lower than that required by other potential therapies.

Method of treatment for myocardial infarction

Growing community of inventors

Brookline, MA, United States of America

Herman K Gold