Iq Corporation Bv

Iq Therapeutics Bv

Rijksuniversiteit Groningen

Academisch Ziekenhuis Groningen

Omero Biosolutions Bv.

Iq Corporation

Herman Groen

Sibrand Poppema

Rob P Van Weeghel

Peter Zwiers

Judith Van Der Leij

Lydia Visser

Hans H Westra

Anke Van Den Berg

Jan Maarten Van Dijl

Girbe Buist

Hendrik Petrus Jozef Bonarius

Neeltje Margaretha Kooi

Anke Ven Den Berg

Goffe Sytse Elsinga

Christine Cool-Kebbedies

Kunja S Slopsema

Hans Westra

The invention relates to the field of immunology and vaccine development. In particular, it relates to antibodies and fragments thereof againstand to therapeutic and diagnostic uses thereof. Provided is an isolated antibody or a functional fragment thereof, which binds to an epitope of the Immunodominant Staphylococcal antigen A (IsaA), wherein said antibody comprises at least four Isa A epitope-binding CDR sequences selected from the group consisting of SEQ ID NO: 1; SEQ ID NO: 2; SEQ ID NO: 3; SEQ ID NO: 4; SEQ ID NO: 5; SEQ ID NO: 6, and functional equivalents thereof having an amino acid sequence that is at least 85% identical to an amino acid sequence of SEQ ID NO: 1-6.

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The invention provides a method of inducing IL-10 production.

Methods of inducing IL-10 production

The invention provides a method of producing a stable lymphocyte culture and methods of producing monoclonal antibodies.

Methods of producing stable B-lymphocytes

The invention fully humanized monoclonal antibodies that neutralize. Also provided are methods of treating or preventing ainfection. The invention also provides methods of passive vaccination of a subject against

Human anthrax toxin neutralizing monoclonal antibodies and methods of use thereof

Growing community of inventors

Groningen, Netherlands

Herman Groen