Bristol-Myers Squibb Compnay

Herman Eugene Griffin

Stewart A Cederholm-Williams

Derek A Hollingsbee

Peter A D Edwardson

Michael J Amery

Paul David Sibbons

Horace R Trumbull

Stuart Burnett

Jonathan Hughes

Sally-Anne Rickets

In accordance with the present invention it has been found that a fibrin polymer film formed by applying materials most closely resembling the natural clotting materials to a surgical adhesion formation. Preferred embodiments involve application of a fibrin monomer under polymerizing conditions to the surgical wound site. Unexpectedly, in addition to this improved prevention of adhesions, the more chemically-natural clots, especially the fibrin-monomer based fibrin polymer, also functions as a fibrin sealant, i.e., has adherence, provides hemostasis and promotes wound healing while also functioning as a barrier. In preferred embodiments the novel methods of this invention conveniently use one or more plasma proteins derived from the patient's own blood as to be autologous. Further, the sealant material is preferably substantially free of any added or exogenous enzymes, e.g., thrombin, etc., which catalyze the cleavage of fibrinopeptides A and/or B from fibrinogen. Preferably a fibrin monomer solution is sprayed over the wounded surgical site.

Prevention of post surgical adhesions using a fibrin monomer sealant

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Wakefield, RI, United States of America

Herman Eugene Griffin