Dsm Fine Chemicals Austria Nfg Gmbh & Co. Kg

Dsm Chemie Linz Gmbh

Chemie Linz Gesellschaft M.b.h.

Plc Pharmaceutical Licenses Co. Ltd.

Dsm Fine Chemical Austria Nfg Gmbh & Co Kg

Herfried Griengl

Helmut Schwab

Irma Wirth

Peter Pochlauer

Christoph Reisinger

Ingrid Osprian

Norbert Klempier

Hans Schoemaker

Wolfgang Skranc

Herbert Mayrhofer

Peter Poechlauer

Rudolf Neuhofer

Gerhart Braunegg

Peter P&ouml;chlauer

Christian Werenka

Michael Schmidt

Gerald Kirchner

Irene Kopper

Anna St&uuml;tz De Raadt

Markus Klingler

Meinhard Hasslacher

Michael Schall

Elfriede Marianne Hayn

Martin Fechter

Sepp Kohlwein

Ulrike Pichler

Dean Vincent Johnson

Nongyuan Shi

Gabriele Foidl

The invention relates to a method for producing chiral &#x3b1;-hydroxycarboxylic crystalline acids consisting in transforming cyanhydrins (R) or (S) into &#x3b1;-hydroxycarboxylic acids (R) or (S), respectively by enzymatic hydrolysis in the presence ofNCIMB 11540.

Method for producing chiral &#x3b1;-hydroxycarboxylic acids by enzymatic hydrolysis of chiral cyanohydrins

Method for producing chiral &#x3b1;-hydroxycarboxylic crystalline acids

A process for preparing enantiomer-enriched heterocyclic (R)- and (S)-cyanohydrins of the formula (I),  where R1, R2, R3, R4 independently of one another are H, an unsubstituted or substituted C&#x2013;C-alkyl, alkenyl or alkynyl radical, where one or more carbon atoms in the chain can be replaced by an oxygen atom, a nitrogen atom, a sulfur atom, an SO or an SOgroup, an unsubstituted or substituted aryl or heteroaryl radical or heterocyclic radical or halogen, hydroxyl, NR5R6, acetyl, oxo, C&#x2013;C-carbalkoxy, C&#x2013;C-carbalkoxyamino, COOR7, cyano, amide, benzoylamino or NO, R5 and R6 are H, C&#x2013;C-alkyl radical, phenyl radical, benzyl radical or COOR7, or together form a C&#x2013;C-alkylene or heteroalkylene radical, R7 is H or C&#x2013;C-alkyl, n is 0, 1, 2 or 3, X, Y and Z can be an unsubstituted or substituted carbon atom or a radical selected from the group consisting of N, O, S or NR5R6, where R5 and R6 are as defined above, SO or SO, and at least one of the radicals X, Y and Z is not a carbon atom, where the compounds of the formula (I) can have one or more double bonds in the ring, with the proviso that in a 5-membered ring the double bond is not conjugated with the &#x2014;C(OH)CN-group, and/or can be anellated and/or bridged, by reacting a ketone of the formula (II),  where R1, R2, R3, R4, X, Y, Z and n have the meanings above, with an (R)- or (S)-hydroxynitrile lyase in an organic, aqueous or two-phase system, or in emulsion, in the presence of a cyanide group donor.

Process for preparing heterocyclic (R)- and (S)-cyanohydrins

Process for the stereoselective reduction of chiral &agr;- or &bgr;-keto esters which have a chiral center in the &ggr; position in an inert solvent at temperatures from &minus;80 to &plus;50&deg; C. using a reductant obtained by reaction of NaBH and (D)- or (L)-tartaric acid, to give the corresponding diastereomeric hydroxy compounds in each case.

Process for selective reduction

An enantioselective process for the preparation of the (S)-enantiomer of an optically active cyanohydrin by reaction of an aldehyde or of a ketone with a cyanide group donor, in which the aldehyde or the ketone is reacted with a cyanide group donor in an organic diluent in the presence of a recombinant (S)-hydroxynitrile lyase from and the (S)-cyanohydrin formed is isolated from the reaction mixture.

Enzymatic processes for preparing (S)-cyanohydrins

A process for the selective enzymatic hydroxylation of aldehydes and ketones using chiral anchor-protective groups.

Process for the selective enzymatic hydroxylation of aldehydes and ketones

(S)-hydroxynitrilelyase from Hevea brasiliensis

Process for preparing (S)-cyanohydrins by reacting aldehydes or asymmetrical, aliphatic ketones with hydrocyanic acid in the presence of the (S)-oxynitrilase from Hevea brasiliensis at temperatures of up to at most 10.degree. C.

Enzymic process for preparing aliphatic S-cyanohydrins

Enantioselective process for the preparation of the S enantiomer of an optically active cyanohydrin by reacting an aldehyde or an asymmetric ketone with a cyanide group donor in the presence of an S-hydroxynitrile lyase in a diluent and isolating the cyanohydrin formed from the reaction mixture.

Enzymatic process for the enantioselective preparation of optically

Compounds of formula ##STR1## have liver-protecting properties. They are prepared by reacting dehydro-isoeugenol or di-isoeugenol with an oxazolidine of formula ##STR2##

Process for making derivatives of dimers of isoeugenol

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Graz, Austria

Herfried Griengl