Dynatech Corporation

Cadco Corporation

Herbert W Horne, Jr

Joseph D Gresser

Samuel P Sawan

Harli M Dollinger

An intracervical device for the controlled release of an active agent for the prevention of both specific sexually transmitted diseases and pregnancy. The device consists of an entirely erodible polymer, or a combination of an erodible polymer with a skeletal polymer capable of maintaining therefor mechanical properties over long duration in the body. The active agents can include one or more than one of a large family of insoluble metal salts which have been shown to affect sperm motility and/or viability and are effacious in the prevention of sexually transmitted diseases. These agents are slowly released over a defined period of time ranging from one month to up to 18 months in duration due to erosion of the polymer matrix.

Contraceptive intracervical device and novel nonsystemic agents for the

A two-stage device for use within the canal of the cervix of the uterus for the dual and simultaneous purposes of venereal disease prevention and of contraception by prohibiting the migration of sperm through the cervical canal. The two-stage device will consist of (Part A) an insertable member which will be inserted into and be maintained within the cervical canal to which (Part B) a temporary member, effective for upward of a year, can be attached easily with a minimum of discomfort to the patient. [Either or both parts of this two-stage device (at present most probably the temporary part) can incorporate metals such as copper, silver, or others, or suitable compounds thereof, and also spermicidal and pathogenocidal agents, steroids or other drugs.] A unique feature of the invention is its placement within the cervical canal rather than in the fundus or vagina. Part A of the device is designed for semipermanent placement within the cervical canal; its main structural function is to act as a support for Part B which is designed for facile and comfortable removal and replacement and which contains the active agents possibly but not necessarily contained within a slow release matrix. A second unique feature of the invention is the use of magnets to attach Part B to Part A.

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Framingham, MA, United States of America

Herbert W Horne, Jr